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Bovine Metabolome Database



Showing metabocard for SM(d18:0/24:1(15Z)(OH)) (BMDB13469)

Legend: metabolite field enzyme field

Version 1.0
Creation Date 2010-03-24 17:57:27
Update Date 2010-05-12 12:13:44
Accession Number BMDB13469
Common Name SM(d18:0/24:1(15Z)(OH))
Description Sphingomyelin (d18:0/24:1(15Z)(OH))or SM(d18:0/24:1(15Z)(OH))is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath which surrounds some nerve cell axons. It usually consists of phosphorylcholine and ceramide. In humans, sphingomyelin is the only membrane phospholipid not derived from glycerol. Like all sphingolipids, SPH has a ceramide core (sphingosine bonded to a fatty acid via an amide linkage). In addition it contains one polar head group, which is either phosphocholine or phosphoethanolamine. The plasma membrane of cells is highly enriched in sphingomyelin and is considered largely to be found in the exoplasmic leaflet of the cell membrane. However, there is some evidence that there may also be a sphingomyelin pool in the inner leaflet of the membrane. Moreover, neutral sphingomyelinase-2 - an enzyme that breaks down sphingomyelin into ceramide has been found to localise exclusively to the inner leaflet further suggesting that there may be sphingomyelin present there. Sphingomyelin can accumulate in a rare hereditary disease called Niemann-Pick Disease, types A and B. Niemann-Pick disease is a genetically-inherited disease caused by a deficiency in the enzyme Sphingomyelinase, which causes the accumulation of Sphingomyelin in spleen, liver, lungs, bone marrow, and the brain, causing irreversible neurological damage. SMs play a role in signal transduction. Sphingomyelins are synthesized by the transfer of phosphorylcholine from phosphatidylcholine to a ceramide in a reaction catalyzed by sphingomyelin synthase.
Synonyms
  1. C24:1-OH Sphingomyelin
  2. N-(15Z-tetracosenoyl)-sphing-4-enine-1-phosphocholine
Chemical IUPAC Name Not Available
Chemical Formula C47H93N2O7P
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Lipids
Class
  • Sphingolipids
Sub Class
  • Sphingomyelins
Family
  • Mammalian_Metabolite
Species
  • cation; anion; secondary alcohol; quaternary ammonium salt; secondary carboxylic acid amide; phosphoric acid ester; alkene
Biofunction
  • Membrane component; Energy source; Cell signaling
Application
Source
  • Endogenous
Average Molecular Weight 829.224
Monoisotopic Molecular Weight 828.672058
Isomeric SMILES CCCCCCCCCCCCCC=C[C@@H](O)[C@H](COP([O-])(=O)OCC[N+](C)(C)C)NC(=O)CC(O)CCCCCCCCCCCC=C/CCCCCCCC
Canonical SMILES CCCCCCCCCCCCCC=CC(O)C(COP([O-])(=O)OCC[N+](C)(C)C)NC(=O)CC(O)CCCCCCCCCCCC=CCCCCCCCC
KEGG Compound ID C00550 Link Image
BioCyc ID Not Available
BiGG ID Not Available
Wikipedia Link Sphingomyelin Link Image
METLIN ID Not Available
PubChem Compound Not Available
PubChem Substance Not Available
ChEBI ID Not Available
CAS Registry Number Not Available
InChI Identifier InChI=1/C47H93N2O7P/c1-6-8-10-12-14-16-18-20-21-22-23-24-25-27-28-30-32-34-36-38-44(50)42-47(52)48-45(43-56-57(53,54)55-41-40-49(3,4)5)46(51)39-37-35-33-31-29-26-19-17-15-13-11-9-7-2/h20-21,37,39,44-46,50-51H,6-19,22-36,38,40-43H2,1-5H3,(H-,48,52,53,54)/b21-20-,39-37+/t44?,45-,46+/m0/s1
Synthesis Reference Not Available
Melting Point (Experimental) Not Available
Experimental Water Solubility Not Available Source: PhysProp
Predicted Water Solubility 3.06e-05 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 0
State Solid
Experimental LogP/Hydrophobicity Not Available Source: PhysProp
Predicted LogP/Hydrophobicity 5.81 [Predicted by ALOGPS] Calculated using ALOGPS
Material Safety Data Sheet (MSDS) Not Available
MOL File Show
SDF File Show
PDB File Show
2D Structure
3D Structure
Experimental PDB ID Not Available
Experimental 1H NMR Spectrum Not Available
Experimental 13C NMR Spectrum Not Available
Experimental 13C HSQC Spectrum Not Available
Predicted 1H NMR Spectrum Not Available
Not Available
Predicted 13C NMR Spectrum Not Available
Not Available
Mass Spectrum Not Available
Simplified TOCSY Spectrum Not Available
BMRB Spectrum Not Available
Cellular Location
  • Membrane
Biofluid Location
  • Rumen
Tissue Location Not Available
Concentrations (Normal)
Biofluid Breast_Milk
Value 0.61 +/- 0.0243 uM
Age N/A
Sex N/A
Condition Normal
Comments Quantified by DFI-MS in 1% milk
References
Biofluid Breast_Milk
Value 0.55 +/- 0.024 uM
Age N/A
Sex N/A
Condition Normal
Comments Quantified by DFI-MS in skim milk
References
Biofluid Breast_Milk
Value 0.70 +/- 0.014 uM
Age N/A
Sex N/A
Condition Normal
Comments Quantified by DFI-MS in 2% milk
References
Biofluid Breast_Milk
Value 0.67 +/- 0.032 uM
Age N/A
Sex N/A
Condition Normal
Comments Quantified by DFI-MS in 3.25% milk
References
Biofluid Rumen
Value 0.003 +/- 0.003 uM
Age N/A
Sex N/A
Condition Normal
Comments Not Available
References
  • The rumen metabolome (in preparation)
Concentrations (Abnormal) Not Available
Pathway Names Not Available
HMDB Pathways Not Available
KEGG Pathways Not Available
SimCell Pathways Not Available
General References
  1. Wikipedia Link Image