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Bovine Metabolome Database



Showing metabocard for Glycerol (BMDB00131)

Legend: metabolite field enzyme field

Version 1.0
Creation Date 2005-11-16 15:48:42
Update Date 2009-07-03 14:32:28
Accession Number BMDB00131
Common Name Glycerol
Description Glycerol is an important component of triglycerides (i.e. fats and oils) and of phospholipids. glycerol is a three-carbon substance that forms the backbone of fatty acids in fats. When the body uses stored fat as a source of energy, glycerol and fatty acids are released into the bloodstream. The glycerol component can be converted to glucose by the liver and provides energy for cellular metabolism.
Synonyms
  1. 1,2,3-Trihydroxypropane
  2. Bulbold
  3. Cristal
  4. E 422
  5. Emery 916
  6. Glyceol Opthalgan
  7. Glycerin
  8. Glycerine
  9. Glyceritol
  10. Glycerol
  11. Glycyl alcohol
  12. Glyrol
  13. Glysanin
  14. IFP
  15. Incorporation factor
  16. Mackstat H 66
  17. Osmoglyn
  18. Pricerine 9091
  19. Propanetriol
  20. RG-S
  21. Trihydroxypropane
  22. Tryhydroxypropane
Chemical IUPAC Name 1,2,3-Propanetriol
Chemical Formula C3H8O3
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Alcohols
Class
  • Alcohols and Polyols
Sub Class
  • Triols
Family
  • Mammalian_Metabolite
Species
  • primary alcohol; secondary alcohol; 1,2-diol
Biofunction
  • Component of Glycerolipid metabolism; Component of Glycerophospholipid metabolism
Application
Source
  • Endogenous
Average Molecular Weight 92.094
Monoisotopic Molecular Weight 92.047340
Isomeric SMILES OCC(O)CO
Canonical SMILES OCC(O)CO
KEGG Compound ID C00116 Link Image
BioCyc ID GLYCEROL Link Image
BiGG ID 33915 Link Image
Wikipedia Link Glycerol Link Image
METLIN ID 105 Link Image
PubChem Compound 753 Link Image
PubChem Substance 11532003 Link Image
ChEBI ID 17754 Link Image
CAS Registry Number 56-81-5
InChI Identifier InChI=1/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
Synthesis Reference Yang, Yifang. Purification of glycerol. Faming Zhuanli Shenqing Gongkai Shuomingshu (2007), 3pp.
Melting Point (Experimental) 20
Experimental Water Solubility 1000.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)] Source: PhysProp
Predicted Water Solubility 1.17e+03 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 0
State Liquid
Experimental LogP/Hydrophobicity -1.76 [HANSCH,C ET AL. (1995)] Source: PhysProp
Predicted LogP/Hydrophobicity -1.93 [Predicted by ALOGPS]; -1.9 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show
SDF File Show
PDB File Show
2D Structure
3D Structure
Experimental PDB ID Not Available
Experimental 1H NMR Spectrum Download Spectrum
Download FID (Varian)
Show Experimental Conditions Link Image
Experimental 13C NMR Spectrum Download Spectrum
Download FID (Bruker)
Show Experimental Conditions Link Image
Experimental 13C HSQC Spectrum Download Spectrum
Download FID (Bruker)
Show Experimental Conditions Link Image
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum
Low Energy
Download File
Show Experimental Conditions Link Image
Medium Energy
Download File
Show Experimental Conditions Link Image
High Energy
Download File
Show Experimental Conditions Link Image
Simplified TOCSY Spectrum Show Image
Show Peaklist
BMRB Spectrum Show Image
Show Peaklist
Cellular Location
  • Cytoplasm (Predicted from LogP)
  • Extracellular
  • mitochondria
Biofluid Location
  • Rumen
Tissue Location
Tissue References
Adipose Tissue
Bladder
Brain
Epidermis
Kidney
Liver
Muscle
Myelin
Nerve Cells
Neuron
Pancreas
Placenta
Skeletal Muscle
Skin
Spleen
Stratum Corneum
Testes
Thyroid Gland
Concentrations (Normal)
Biofluid Rumen
Value 144.04 +/- 54.94 uM
Age N/A
Sex N/A
Condition Normal
Comments Not Available
References
  • The rumen metabolome (in preparation)
Concentrations (Abnormal)
Biofluid Rumen
Value 265.46 +/- 68.57 uM
Age N/A
Sex N/A
Condition Rumen acidosis
Comments Not Available
References
  • The rumen metabolome (in preparation)
Pathway Names
  • Galactose Metabolism
  • Glycerolipid Metabolism
HMDB Pathways
Name Galactose Metabolism
Image Show Link Image
Name Glycerolipid Metabolism
Image Show Link Image
KEGG Pathways
Name Galactose Metabolism
Image Show Link Image
Name Glycerolipid Metabolism
Image Show Link Image
SimCell Pathways
Name Galactose Metabolism
Image Show Link Image
Graph
SBML
Name Glycerolipid Metabolism
Image Show Link Image
Graph
SBML
General References
  1. Wikipedia Link Image
Metabolic Enzymes
  1. Glycerol kinase
  2. Putative glycerol kinase 5
  3. Diacylglycerol kinase alpha
  4. Monoacylglycerol lipase ABHD6
  5. Hormone-sensitive lipase
  6. Monoacylglycerol lipase ABHD12
Enzyme 1 [top]
Enzyme 1 ID 930
Enzyme 1 Name Glycerol kinase
Enzyme 1 Synonyms
  1. ATP:glycerol 3-phosphotransferase
  2. Glycerokinase
  3. GK
Enzyme 1 Gene Name GK
Enzyme 1 Protein Sequence >Glycerol kinase
MASAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEI
LQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVVWLDLRTQ
STVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEDRALFGTIDS
WLIWSLTGGASGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFEIPMKILPNVRSSSEIY
GLMKISHSPKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGRKCV
FSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGT
SYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRD
CGIPLSHLQVDGGMTNNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSL
EPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSSESGDPSIFCSLPLGF
FIVSSVVMLIGARYLSGMP
Enzyme 1 Number of Residues 559
Enzyme 1 Molecular Weight 61261.0
Enzyme 1 Theoretical pI 5.93
Enzyme 1 GO Classification
Function
Process
Component
Enzyme 1 General Function Energy production and conversion
Enzyme 1 Specific Function Key enzyme in the regulation of glycerol uptake and metabolism
Enzyme 1 Pathways
  • Polyol metabolism
  • glycerol degradation via glycerol kinase pathway
  • sn-glycerol 3-phosphate from glycerol:step 1/1
Enzyme 1 Reactions Not Available
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 113912034 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID Q0IID9 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name GLPK_BOVIN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence >1680 bp
ATGGCATCCGCGAAGAAAGCAGTTTTGGGGCCCTTGGTGGGAGCAGTGGACCAGGGCACC
AGCTCGACGCGCTTTCTGGTTTTCAATTCAAAAACAGCCGAACTACTTAGTCATCATCAA
GTGGAAATAAAACAAGAGTTTCCAAGAGAAGGGTGGGTGGAGCAGGACCCTAAGGAAATT
CTGCAGTCTGTCTATGAGTGTATAGAGAAAACGTGTGAGAAACTCGGGCAGCTCAATATT
GATATTTCCAACATAAAAGCTATTGGTGTCAGTAACCAGAGGGAAACCACTGTAGTCTGG
GACAAGTTAACTGGAGAACCTCTCTACAACGCTGTGGTGTGGCTTGACCTAAGAACCCAG
TCTACTGTTGAGAGTCTTAGTAAAAGAATCCCAGGAAATAATAACTTTGTCAAGTCCAAG
ACAGGCCTTCCACTTAGCACTTATTTCAGTGCGGTGAAGCTTCGTTGGCTCCTTGACAAT
GTGAGAAAAGTTCAAAAGGCCGTTGAAGAAGATAGAGCTCTTTTTGGGACCATTGATTCA
TGGCTTATTTGGAGCTTGACAGGAGGAGCCAGTGGAGGGGTCCATTGTACAGATGTAACA
AATGCAAGCAGGACAATGCTTTTCAACATCCATTCTTTGGAATGGGATAAAGAGCTCTGC
GAATTTTTTGAAATTCCAATGAAAATTCTTCCAAATGTCCGGAGTTCTTCAGAGATCTAT
GGCCTAATGAAAATCTCTCATAGCCCGAAAGCTGGGGCCTTGGAAGGTGTGCCAATATCT
GGGTGTTTGGGAGACCAGTCTGCTGCGTTGGTAGGACAAATGTGCTTCCAAGATGGACAA
GCCAAAAACACGTATGGAACAGGCTGCTTCTTACTATGTAATACAGGCCGTAAGTGTGTA
TTTTCTGAACATGGCCTTCTGACCACAGTGGCTTACAAACTCGGCAGAGATAAACCCGTA
TATTATGCATTAGAAGGTTCAGTAGCTATAGCTGGTGCTGTTATTCGCTGGCTTAGAGAC
AATCTTGGAATTATAAAAAGCTCCGAGGAAATTGAAAAACTTGCTAAAGAAGTAGGTACT
TCTTATGGCTGCTATTTCGTCCCAGCATTTTCGGGGCTGTATGCACCTTATTGGGAGCCC
AGTGCAAGAGGGATCATCTGTGGGCTCACTCAGTTCACCAATAAATGCCATATTGCTTTT
GCTGCATTAGAAGCTGTTTGTTTCCAAACTCGAGAGATTTTGGACGCCATGAACCGTGAC
TGTGGAATTCCACTCAGCCATTTGCAGGTAGATGGTGGAATGACCAACAACAAAATCCTT
ATGCAGTTACAAGCAGACATTCTGTATATTCCAGTAGTGAAACCATCCATGCCTGAAACA
ACTGCTCTGGGAGCCGCCATGGCTGCAGGGGCTGCAGAAGGGGTTGGCGTCTGGAGTCTG
GAGCCTGAGGACTTGTCGGCTGTCACAATGGAGCGATTTGAACCTCAGATCAACGCTGAG
GAAAGTGAAATTCGTTATTCTACATGGAAGAAAGCTGTGATGAAATCAATGGGTTGGGTT
ACAACTCAGTCTTCAGAAAGTGGTGACCCTAGTATCTTCTGTAGTCTGCCCTTGGGCTTT
TTTATAGTGAGTAGCGTGGTAATGTTAATCGGAGCAAGGTACCTCTCAGGTATGCCGTAA
Enzyme 1 GenBank Gene ID BC122692 Link Image
Enzyme 1 GeneCard ID GK Link Image
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Not Available
Enzyme 1 Locus Xp21.3
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References Not Available
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 933
Enzyme 2 Name Putative glycerol kinase 5
Enzyme 2 Synonyms
  1. ATP:glycerol 3-phosphotransferase
Enzyme 2 Gene Name GK5
Enzyme 2 Protein Sequence >Putative glycerol kinase 5
MSEQSTVPEQSASDSRRAGFVLGVDVGSSMIRCHVYDRAARICGSSAQKVESLYPQPGWV
EIDPDVLWLQFVAVIKESVKAAGIETNQIVGLGISTQRATFITWDKKTGKHFHNFISWQD
LRATELVKSWNGSLLMKLIHSSCRVLHFFTRSKQFLAASLFTFTTQHVSLRLAWILQNLT
EVQKAVEEENCCFGTVDTWLLHKLTKGSEFATDFSNASTTGLFDPYEMCWSKIVTSLLSI
PLSLLPPVKDTSHNFGSVDEEIFGVPIPIVALVADQQAAMFGECCFQTGDVKLTMGTGTF
LDINTGNNPQQSVGGFYPLIGWKIGQEVVCLAESNAGDTGTAIEWAQQLDLFTDAAETEK
MAQSLEDSEGVYFVPSFSGLQAPLNDPCACASFMGLKPSTNKYHLVRAILESIAFRNKQL
YETMQKEIHIPVRKIRADGGVCKNSFVMQMTSDLINETIDRPVHIDMSCSGAASLAGLAV
GFWSDKEELKKLRQSEMVFKPQKKWQEYEVNMGNWVKAVKRSMNWYKT
Enzyme 2 Number of Residues 528
Enzyme 2 Molecular Weight 58764.8
Enzyme 2 Theoretical pI 6.15
Enzyme 2 GO Classification
Function
Process
Component
Enzyme 2 General Function Transcription
Enzyme 2 Specific Function ATP + glycerol = ADP + sn-glycerol 3- phosphate
Enzyme 2 Pathways
  • Polyol metabolism
  • glycerol degradation via glycerol kinase pathway
  • sn-glycerol 3-phosphate from glycerol:step 1/1
Enzyme 2 Reactions Not Available
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 61553643 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID Q08D86 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name GLPK5_BOVIN Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >1113 bp
ATGTCAGAACAGTCTACGGTCCCGGAGCAGAGCGCGTCGGACTCGCGGCGCGCAGGCTTC
GTGCTGGGGGTGGACGTAGGCAGCTCGATGATTCGCTGCCACGTCTATGACCGCGCGGCA
CGAATCTGCGGCTCCAGCGCGCAGAAGGTAGAAAGTCTTTATCCTCAGCCTGGCTGGGTT
GAAATTGATCCTGATGTTCTCTGGCTTCAGTTTGTTGCTGTAATAAAGGAATCTGTCAAA
GCTGCAGGAATAGAAACAAATCAAATTGTTGGTCTTGGCATTTCAACACAGAGAGCAACT
TTTATCACATGGGACAAGAAAACGGGAAAGCATTTCCACAACTTCATTAGTTGGCAAGAC
CTACGAGCTACTGAACTTGTAAAATCTTGGAATGGTTCTCTTTTAATGAAGCTCATACAC
AGTTCCTGCCGAGTACTGCACTTTTTCACTAGAAGTAAACAATTTCTAGCAGCCAGTTTG
TTCACTTTCACAACTCAGCATGTTTCTTTGAGATTGGCCTGGATTTTGCAGAACCTGACT
GAGGTGCAAAAGGCAGTGGAAGAAGAAAATTGCTGCTTTGGGACTGTTGATACCTGGTTG
TTACATAAGCTCACAAAAGGTTCTGAATTTGCCACAGATTTTTCAAATGCCAGCACAACT
GGACTTTTTGACCCATATGAGATGTGTTGGAGCAAGATCGTTACCTCCCTGCTTTCAATC
CCGCTCTCTCTCCTGCCTCCTGTGAAGGATACGAGCCACAATTTTGGATCAGTGGATGAA
GAGATATTTGGTGTGCCTATACCAATAGTGGCCTTGGTCGCTGACCAGCAAGCAGCCATG
TTTGGAGAATGCTGCTTTCAAACAGGAGATGTGAAGTTAACCATGGGAACTGGGACGTTT
TTAGATATTAATACTGGAAATAACCCTCAACAGAGTGTTGGAGGCTTTTATCCATTAATT
GGGTGGAAGATCGGGCAAGAAGTGGTGTGCTTAGCTGAAAGCAATGCGGGAGACACAGGC
ACTGCCATAGAGTGGGCTCAGCAGTTAGGTAGAATGAAAAAGCATTCAAAAAACAAGAAC
AAGGGGATTATTTCCCCACTCTCTGTTCTGTAG
Enzyme 2 GenBank Gene ID BT021588 Link Image
Enzyme 2 GeneCard ID GK5 Link Image
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Chromosome:3
Enzyme 2 Locus 3q23
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References
  1. [PubMed Link Image]
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 1064
Enzyme 3 Name Diacylglycerol kinase alpha
Enzyme 3 Synonyms
  1. DAG kinase alpha
  2. Diglyceride kinase alpha
  3. DGK-alpha
Enzyme 3 Gene Name DGKA
Enzyme 3 Protein Sequence >Diacylglycerol kinase alpha
MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAEYLQGDAIGYEGFQQFLKIY
LEVDNVPDHLSQALFQSFQTGYYIEDTVREDVVCLSDVSCYFSLLEGGRPEDKLEFTFKL
YDTDRNGILDSSEVDRIIIQMMRMAEYLDWDVSELRPILQEMMKEIDYDGSGSVSLAEWL
RAGATTVPLLVLLGLEMTLKDNGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKYI
VHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLVGLHCV
WCHLEIHDDCLPAMGHECDCGLLRDHILPPSSIYPSVLASGQERKTSKISQKTMDDLSLS
TSEALRIDPVSNTHPLLVFVNPKSGGKQGERVLWKFQYLLNPRQVFNLLKDGPEPGLRFF
RDVPDYRILVCGGDGTVGWILESIDKANLPFVPPVAVLPLGTGNDLARCLRWGGGYEGQN
LGKILKDLETSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIMR
EKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLN
IPSTHGGSNLWGDTKRPHGDIHGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEG
AIEIGQIYTKLKNAGHRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHRNQMPMLV
GPPPRSSNFFGFLC
Enzyme 3 Number of Residues 734
Enzyme 3 Molecular Weight 82671.3
Enzyme 3 Theoretical pI 6.27
Enzyme 3 GO Classification
Function
Process
Component
Enzyme 3 General Function Involved in calcium ion binding
Enzyme 3 Specific Function Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 117306586 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID A0JN54 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name DGKA_BOVIN Link Image
Enzyme 3 PDB ID Not Available
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >2205 bp
ATGGCCAAGGAGAGGGGCCTAATAAGCCCCAGTGATTTTGCCCAGCTGCAAAAATACATG
GAATACTCCACCAAAAAGGTCAGTGATGTTCTGAAGCTCTTTGAGGATGGTGAAATGGCT
GAATATCTCCAAGGAGATGCCATTGGATACGAGGGGTTCCAGCAATTCCTGAAAATCTAC
CTGGAGGTGGATAATGTTCCAGATCACCTAAGCCAGGCACTGTTTCAGTCCTTCCAGACT
GGCTACTACATAGAAGACACTGTAAGAGAAGATGTGGTGTGTCTCAGTGATGTCTCCTGC
TACTTTTCTCTTCTGGAGGGTGGCCGGCCAGAAGACAAGCTAGAATTCACCTTCAAGCTG
TACGACACGGACAGAAATGGGATCCTGGACAGCTCAGAAGTGGACAGGATCATCATACAG
ATGATGCGAATGGCTGAATACCTGGATTGGGATGTGTCTGAGCTGAGGCCGATTCTTCAA
GAGATGATGAAAGAGATTGACTATGATGGCAGTGGCTCTGTGTCCCTGGCTGAGTGGCTC
CGGGCTGGGGCCACCACCGTGCCACTGCTCGTGCTGCTGGGCCTGGAGATGACCCTGAAG
GACAATGGGCAGCACATGTGGAGACCCAAGAGATTCCCCCGACCAGTCTACTGCAACCTG
TGCGAGTCGAGCATTGGTCTTGGCAAACAGGGGCTGAGCTGTAACCTCTGTAAATACATC
GTTCACGACCAATGTGCCATGAAGGCCCTGCCCTGTGAAGTCAGCACCTATGCCAAGTCT
CGGAAGGACATTGGTGTCCAATCACACGTGTGGGTGCGAGGAGGCTGTGAATCTGGACGG
TGTGACCGCTGTCAGAAAAAGATCCGGATCTACCACAGTCTGGTTGGGCTGCATTGTGTG
TGGTGCCACCTAGAGATCCATGATGACTGCCTTCCAGCCATGGGCCATGAGTGTGACTGT
GGGCTGCTCCGAGATCACATCCTGCCTCCGTCTTCCATCTATCCCAGCGTCCTGGCCTCT
GGACAGGAGCGTAAAACTAGCAAAATAAGCCAGAAGACCATGGATGATTTAAGTTTGAGC
ACTTCTGAGGCTCTGCGGATTGATCCTGTTTCTAACACCCACCCACTTCTGGTCTTTGTG
AACCCCAAGAGTGGCGGGAAGCAAGGCGAGAGGGTGCTTTGGAAATTCCAGTATCTGCTG
AACCCTCGACAGGTGTTCAACCTCCTAAAGGATGGTCCTGAGCCAGGACTCAGATTCTTC
AGAGATGTTCCTGATTACAGGATTTTGGTGTGCGGCGGAGATGGCACAGTAGGCTGGATT
CTAGAGTCCATTGACAAAGCCAACTTGCCTTTTGTGCCTCCTGTCGCTGTGTTGCCCCTG
GGCACTGGAAATGATCTGGCTCGTTGCCTAAGATGGGGAGGAGGGTATGAGGGACAGAAT
CTGGGGAAGATCCTCAAGGATTTAGAGACAAGTAAGGTGGTACATATGGATCGATGGTCT
GTGGAGGTGATACCCCAACAAACTGAAGAAAAGAGTGACCCAGTCCCCTTTCAAATCATC
AATAACTACTTCTCCATCGGTGTGGATGCCTCTATTGCTCACCGATTCCACATTATGCGA
GAGAAATATCCTGAGAAGTTCAACAGCAGAATGAAGAACAAGCTATGGTACTTCGAATTT
GCCACTTCTGAATCCATCTTCTCAACGTGCAAAAAGCTGGAGGAATCTTTGACAGTTGAG
ATCTGTGGGAAACCACTGGATCTGAGCAACCTGTCCCTAGAAGGCATTGCAGTGCTGAAC
ATCCCAAGCACACATGGTGGCTCCAATCTCTGGGGTGACACCAAGAGACCACATGGCGAT
ATCCATGGGATCAACCAGGCCTTAGGTGCTACTGCCAAAGTCATCACCGACCCTGATATC
CTGAAGACCTGTGTACCAGACCTAAGTGACAAGCGGCTGGAAGTAGTGGGGCTGGAGGGT
GCAATTGAGATAGGCCAGATCTATACCAAGCTCAAGAATGCTGGACATCGGCTGGCCAAG
TGCTCTGAGATCACCTTCCACACCACAAAAACCCTCCCCATGCAAATTGACGGAGAACCC
TGGATGCAGACACCTTGTACAATCAAGATCACCCACAGGAACCAGATGCCTATGCTCGTG
GGCCCACCCCCTCGCTCCTCCAATTTTTTTGGCTTCTTGTGCTAA
Enzyme 3 GenBank Gene ID BC126521 Link Image
Enzyme 3 GeneCard ID DGKA Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Chromosome:1
Enzyme 3 Locus 12q13.3
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References Not Available
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 1279
Enzyme 4 Name Monoacylglycerol lipase ABHD6
Enzyme 4 Synonyms
  1. 2-arachidonoylglycerol hydrolase
  2. Abhydrolase domain-containing protein 6
Enzyme 4 Gene Name ABHD6
Enzyme 4 Protein Sequence >Monoacylglycerol lipase ABHD6
MDLDVVNMFVIAGGTLALPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVRHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSMVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IDGQVKRIHQFVECLKLNKKPFHLVGTSMGGHVAGVYAAHYPSDVCSLSLVCPAGLQYST
DNKFVQRLKELQESAAVEKIPLIPTTPKEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
TFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANSQVEL
LENCGHSVVMERPRKTAKLLVDFLASVHSTDNSKKLD
Enzyme 4 Number of Residues 337
Enzyme 4 Molecular Weight 38352.5
Enzyme 4 Theoretical pI 9.12
Enzyme 4 GO Classification
Function
Process
Component
Enzyme 4 General Function Involved in acylglycerol lipase activity
Enzyme 4 Specific Function Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways (By similarity)
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • 20-42
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 94534813 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID Q1LZ86 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name ABHD6_BOVIN Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >1014 bp
ATGGATCTTGACGTGGTTAACATGTTTGTGATTGCGGGTGGGACACTGGCCCTTCCGATC
CTGGCATTCGTAGCCTCTTTTCTCCTGTGGCCTTCAGCCCTGATAAGAATCTATTACTGG
TACTGGCGGAGGACGCTGGGCATGCAGGTCCGCTATGTGCGCCACGAAGACTATCAGTTC
TGCTACTCCTTCCGTGGCAGGCCTGGCCACAAACCTTCCATCCTCATGCTCCACGGGTTC
TCTGCCCACAAGGACATGTGGCTCAGCATGGTCAAGTTCCTCCCGAAGAACCTGCACCTG
GTCTGCGTGGACATGCCAGGGCATGAAGGCACCACTCGGTCCTCACTGGATGACCTGTCC
ATAGATGGGCAAGTCAAGAGGATACACCAGTTTGTAGAATGCCTCAAGCTGAACAAAAAG
CCCTTCCACCTGGTAGGCACCTCCATGGGCGGCCACGTGGCTGGGGTGTATGCTGCTCAC
TACCCATCAGACGTCTGCAGCCTGTCCCTTGTGTGTCCTGCGGGTCTGCAGTACTCAACT
GATAATAAATTTGTGCAACGGCTCAAAGAACTGCAGGAGTCGGCCGCCGTAGAGAAGATT
CCCTTGATCCCGACCACCCCGAAGGAGATGAGTGAGATGCTGCAGCTCTGCTCCTACGTA
CGCTTCAAGGTGCCCCAGCAGATCCTGCAGGGCCTTGTTGATGTCCGCATCCCTCACAAC
ACCTTCTACCGAAAGCTGTTTTTGGAAATCGTCAGTGAGAAGTCGAGATACTCCCTCCAT
CAGAACATGGACAAGATTAAGGTCCCCACGCAGATCATCTGGGGGAAACAAGACCAGGTG
CTCGATGTGTCCGGGGCAGACATGTTGGCCAAGTCAATCGCCAACTCCCAGGTGGAGCTC
CTGGAAAACTGTGGGCACTCAGTGGTGATGGAGAGGCCCAGGAAGACAGCCAAGCTCCTT
GTCGACTTCTTGGCTTCTGTACACAGCACAGACAACAGCAAGAAGCTGGACTGA
Enzyme 4 GenBank Gene ID BC116144 Link Image
Enzyme 4 GeneCard ID ABHD6 Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Chromosome:3
Enzyme 4 Locus 3p14.3
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References Not Available
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 1280
Enzyme 5 Name Hormone-sensitive lipase
Enzyme 5 Synonyms
  1. HSL
Enzyme 5 Gene Name LIPE
Enzyme 5 Protein Sequence >Hormone-sensitive lipase
MDLRTMTQSLVTLAEDNMAFFSSQGPGETARRLTGVFAGIREQALGLEPALGRLLSVAHL
FDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQ
LRALAYYAQRLLTTNQPGRLFFEGDERVIADFLREYVTLHKGCFYGRCLGFQFTPAIRPF
LQTISIGLVSFGEHYKRNETGISVTASSLFTDGRFAIDPELRGAEFERIIQNLDVHFWKA
FWNITEIQVLSSLANMASTTVRVSRLLSLPPVAFEMPLTSDPELTVTISPPLAHTGPGPV
LVRLISYDLREGQDSKELSSFVRSEGPRSLELRLRPQQAPRSRALVVHIHGGGFVAQTSK
SHEPYLKSWAQELGAPILSIDYSLAPEAPFPRALEECFYAYCWAVKHCALLGSTGERICL
AGDSAGGNLCFTVSLRAAAYGVRVPDGIMAAYPATMLQSTASPSRLLSLMDHLLPLSVLS
KCVSTYAGAETEDHPDSDQKALGVMGLVQRDTALLLRDLRLGASSWLNSFLELGGQKSHL
KSVSKTEPMRRSVSEAALTQPEGSLGTDSLKSLKLHDLGLRNSSDTTDTPELSLSAETLG
PSAPSTINFLLGSEDGSEMSKAPEELNNKDRVRGVGAAFPEGFHPRRCSQGAMWMPLYSA
PIVKNPSMSPLLAPDSMLQTLPPVHIVACALDPMLDDSVMFARRLRGLGQPVTLRVAEDL
PHGFLSLAALCRETRQAAALCVERIRLILNLPGPPV
Enzyme 5 Number of Residues 756
Enzyme 5 Molecular Weight 82639.8
Enzyme 5 Theoretical pI 7.16
Enzyme 5 GO Classification
Function
Process
Component
Enzyme 5 General Function Lipid transport and metabolism
Enzyme 5 Specific Function In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production
Enzyme 5 Pathways
  • Glycerolipid metabolism
  • triacylglycerol degradation
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • None
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 119552663 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID P16386 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name LIPS_BOVIN Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >2271 bp
ATGGACCTGCGCACCATGACACAGTCGCTGGTGTCCCTGGCAGAGGACAACATGGCCTTC
TTCTCCAGCCAGGGCCCCGGGGAGACGGCCCGGCGGCTGACGGGCGTCTTTGCGGGCATT
CGGGAGCAGGCCCTGGGGCTGGAGCCGGCCCTGGGCCGCCTGCTGAGCGTGGCGCACCTC
TTTGACCTGGACACAGAGACGCCGGCCAATGGGTACCGCAGCCTGGTGCACACGGCCCGC
TGCTGCCTGGCACACCTGCCGCACAAATCGCGCTACGTGGCCTCCAACCGCCGCAGCATC
TTCTTTCGCACCAGCCACAACCTGGCCGAACTCGAGGCCTACCTGGCCGCCCTCACCCAG
CTCCGCGCTCTGGCTTACTACGCCCAGCGCCTGCTGACCACCAACCAGCCCGGGAGGCTC
TTCTTTGAGGGTGATGAGAGGGTAATTGCCGACTTCCTACGAGAGTACGTCACGCTGCAC
AAAGGCTGCTTCTACGGCCGCTGCCTGGGTTTCCAGTTCACACCTGCCATCCGGCCGTTC
CTGCAGACCATCTCCATCGGACTGGTGTCCTTCGGGGAGCACTACAAACGAAACGAGACT
GGCATCAGTGTGACCGCCAGCTCCCTCTTCACTGACGGCCGCTTTGCCATCGACCCCGAG
CTGCGTGGGGCCGAGTTTGAGCGGATCATTCAGAACCTAGACGTGCACTTCTGGAAAGCT
TTCTGGAATATCACCGAGATCCAGGTGCTATCGTCTCTAGCAAACATGGCCTCAACCACC
GTGAGGGTGAGCCGCCTGCTCAGCCTGCCACCCGTCGCCTTTGAAATGCCTCTGACCTCG
GACCCCGAGCTCACAGTCACCATCTCGCCCCCGCTGGCCCACACAGGCCCTGGGCCTGTC
CTCGTCAGGCTCATCTCCTATGACCTGCGGGAAGGACAGGACAGCAAGGAGCTCAGCAGC
TTCGTGAGGTCCGAGGGCCCCAGGAGCCTGGAGCTGCGGCTGCGCCCCCAGCAGGCACCC
CGCTCCAGGGCCCTGGTGGTGCACATCCACGGCGGCGGCTTCGTGGCCCAGACCTCCAAG
TCGCACGAGCCTTACCTCAAGAGCTGGGCCCAGGAGCTGGGCGCCCCCATCCTCTCCATC
GACTACTCCCTGGCCCCAGAGGCCCCCTTCCCCCGGGCGCTCGAAGAGTGCTTCTATGCC
TACTGCTGGGCCGTCAAGCACTGCGCCCTGCTCGGCTCAACAGGTGAGCGGATATGCCTC
GCTGGAGACAGCGCCGGCGGGAACCTCTGCTTCACCGTGTCCCTTCGGGCAGCGGCCTAC
GGGGTGCGGGTGCCCGATGGCATCATGGCAGCCTACCCGGCCACCATGCTGCAGTCCACC
GCCTCTCCTTCCCGCCTGCTGAGCCTCATGGACCACCTGCTGCCTCTCAGCGTGCTCTCC
AAGTGCGTCAGCACCTATGCCGGTGCGGAGACTGAGGACCACCCCGACTCAGACCAGAAG
GCGCTGGGTGTGATGGGGCTCGTGCAGCGGGACACGGCCCTGCTCTTGCGAGACCTCCGG
CTGGGCGCCTCCTCGTGGCTCAACTCCTTCTTGGAGTTGGGTGGGCAAAAGTCCCACCTG
AAATCAGTGTCCAAGACAGAGCCAATGCGGCGCAGTGTGTCTGAAGCAGCCCTGACCCAG
CCGGAGGGCTCACTGGGAACCGACTCCCTCAAAAGCCTGAAGCTGCATGACCTGGGCCTC
AGGAACAGCAGTGACACAACAGACACGCCAGAGCTGTCACTGTCCGCGGAGACACTCGGC
CCCTCCGCACCCTCAACCATCAACTTCTTACTTGGATCTGAGGATGGATCTGAAATGTCT
AAGGCCCCAGAGGAGCTGAACAACAAGGACCGAGTTCGAGGTGTGGGCGCCGCCTTCCCC
GAGGGTTTCCACCCACGGCGCTGCAGCCAGGGTGCCATGTGGATGCCCCTCTACTCGGCC
CCCATCGTCAAGAATCCCTCCATGTCACCGCTGCTGGCACCCGACAGCATGCTGCAGACT
CTGCCACCTGTGCACATCGTGGCCTGCGCGCTGGATCCCATGCTGGACGACTCGGTCATG
TTCGCGCGGCGGCTCCGCGGCCTGGGCCAGCCCGTGACGCTGCGCGTGGCGGAGGACCTG
CCGCACGGCTTCCTGAGCCTGGCGGCTTTGTGCCGGGAGACGCGGCAGGCAGCCGCGCTG
TGCGTGGAGCGCATCCGTCTCATCCTCAATCTTCCCGGGCCGCCGGTCTGA
Enzyme 5 GenBank Gene ID EF140760 Link Image
Enzyme 5 GeneCard ID LIPE Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Chromosome:1
Enzyme 5 Locus 19q13.2
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References
  1. [PubMed Link Image]
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 1281
Enzyme 6 Name Monoacylglycerol lipase ABHD12
Enzyme 6 Synonyms
  1. 2-arachidonoylglycerol hydrolase
  2. Abhydrolase domain-containing protein 12
Enzyme 6 Gene Name ABHD12
Enzyme 6 Protein Sequence >Monoacylglycerol lipase ABHD12
MRKRTEPVALEHERRTASGSPSAGPAAAALDADCRLKQNLCLAGPGPAEPRCAADAGMKR
ALGRRKGLCFRLRKILFFVLGLYVAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKRPQDQ
GLNHTCNYYLQPEEDVTIGVWHTVPTVWWKNAQGKDQMWYEDALSSSHPIILYLHGNAGT
RGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKVRSGDNPV
YIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWF
FLDPITSSGIQFANDENVKHISCSLLILHAEDDPVVPFQLGRKLYNIAAPSRSFRDFKVQ
FIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPGRQH
Enzyme 6 Number of Residues 398
Enzyme 6 Molecular Weight 45219.4
Enzyme 6 Theoretical pI 8.96
Enzyme 6 GO Classification
Function
Process
Component
Enzyme 6 General Function Involved in acylglycerol lipase activity
Enzyme 6 Specific Function Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways (By similarity)
Enzyme 6 Pathways Not Available
Enzyme 6 Reactions Not Available
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • None
Enzyme 6 Transmembrane Regions
  • 75-95
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 115305146 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID Q08DW9 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name ABD12_BOVIN Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >1197 bp
ATGAGGAAGCGGACCGAGCCCGTCGCCCTGGAGCATGAACGCCGTACCGCCTCGGGCTCG
CCCTCCGCCGGCCCGGCCGCCGCGGCGCTGGACGCCGACTGCCGCCTGAAGCAGAACCTG
TGCCTAGCGGGCCCTGGGCCGGCCGAGCCGCGCTGCGCCGCGGACGCGGGCATGAAGCGG
GCGCTGGGCAGGCGAAAGGGCCTGTGCTTCCGACTGAGGAAGATACTCTTCTTTGTCCTG
GGATTGTATGTGGCCATTCCATTTCTCATCAAACTATGTCCTGGGATACAGGCCAAACTG
ATTTTCTTGAATTTCGTGCGGGTTCCCTATTTCATTGATTTGAAAAGACCACAGGATCAA
GGTTTGAATCACACCTGTAATTACTACCTCCAGCCAGAGGAAGACGTAACCATTGGAGTC
TGGCACACGGTCCCCACTGTCTGGTGGAAGAATGCCCAGGGGAAGGACCAGATGTGGTAC
GAGGATGCCCTGTCTTCCAGCCACCCGATCATCCTGTACCTGCATGGGAACGCGGGCACC
AGAGGCGGCGACCACCGGGTGGAGCTTTACAAGGTGCTGAGTTCCCTCGGCTACCACGTG
GTCACCTTTGACTACAGAGGTTGGGGTGACTCAGTAGGAACGCCGTCGGAGCGGGGCATG
ACGTATGATGCACTCCATGTTTTTGACTGGATCAAAGTGCGAAGTGGAGACAACCCTGTG
TATATTTGGGGCCATTCTCTTGGCACCGGAGTGGCCACAAACCTGGTGCGGCGCCTCTGT
GAGCGAGAGACTCCTCCAGATGCCCTCATCTTGGAATCTCCATTCACTAATATCCGTGAA
GAAGCCAAGAGCCATCCGTTCTCAGTGATCTATCGATATTTCCCTGGGTTTGACTGGTTC
TTCCTTGATCCCATCACAAGCAGTGGAATTCAGTTTGCAAATGATGAAAATGTGAAGCAC
ATCTCCTGCTCCCTGCTCATCCTGCATGCCGAGGACGACCCGGTCGTGCCCTTCCAGCTC
GGCAGAAAGCTCTACAACATCGCCGCACCGTCACGCAGCTTCCGGGACTTTAAGGTTCAG
TTCATCCCCTTCCACTCGGACCTTGGCTACAGGCACAAGTACATCTACAAGAGCCCCGAG
CTCCCGCGGATCCTGAGGGAGTTCCTGGGGAAGTCGGAACCGGGACGCCAGCACTGA
Enzyme 6 GenBank Gene ID BC123534 Link Image
Enzyme 6 GeneCard ID ABHD12 Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Chromosome:2
Enzyme 6 Locus 20p11.21
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References Not Available
Enzyme 6 Metabolite References Not Available