Version |
1.0 |
Creation Date |
2005-11-16 15:48:42 |
Update Date |
2009-07-02 10:39:17 |
Accession Number |
BMDB00067 |
Common Name |
Cholesterol |
Description |
Cholesterol is a sterol (a combination steroid and alcohol) and a lipid found in the cell membranes of all body tissues, and transported in the blood plasma of all animals. The name originates from the Greek chole- (bile) and stereos (solid), and the chemical suffix -ol for an alcohol, as researchers first identified cholesterol (C27H45OH) in solid form in gallstones in 1784. Cholesterol is transported throughout the body via lipoprotein particles. The largest lipoproteins, which primarily transport fats from the intestinal mucosa to the liver, are called chylomicrons. They carry mostly triglyceride fats and cholesterol (that are from food and especially internal cholesterol secreted by the liver into the bile). In the liver, chylomicron particles give up triglycerides and some cholesterol, and are converted into low-density lipoprotein (LDL) particles, which carry triglycerides and cholesterol on to other body cells. In healthy individuals the LDL particles are large and relatively few in number. In contrast, large numbers of small LDL particles are strongly associated with promoting atheromatous disease within the arteries. (Lack of information on LDL particle number and size is one of the major problems of conventional lipid tests.). In conditions with elevated concentrations of oxidized LDL particles, especially small LDL particles, cholesterol promotes atheroma plaque deposits in the walls of arteries, a condition known as atherosclerosis, which is a major contributor to coronary heart disease and other forms of cardiovascular disease. (In contrast, HDL particles have been the only identified mechanism by which cholesterol can be removed from atheroma. Increased concentrations of large HDL particles, not total HDL particles, correlate with lower rates of atheroma progressions, even regression.). There is a world-wide trend to believe that lower total cholesterol levels tend to correlate with lower atherosclerosis event rates (though many studies refute this idea). Due to this reason, cholesterol has become a very large focus for scientific researchers trying to determine the proper amount of cholesterol needed in a healthy diet. However, the primary association of atherosclerosis with cholesterol has always been specifically with cholesterol transport patterns, not total cholesterol per se. For example, total cholesterol can be low, yet made up primarily of small LDL and small HDL particles and atheroma growth rates are high. In contrast, however, if LDL particle number is low (mostly large particles) and a large percentage of the HDL particles are large (HDL is actively reverse transporting cholesterol), then atheroma growth rates are usually low, even negative, for any given total cholesterol concentration. These effects are further complicated by the relative concentration of asymmetric dimethylarginin (ADMA) in the endothelium, since ADMA down-regulates production of nitric oxide, a relaxant of the endothelium. Thus, high levels of ADMA, associated with high oxidized levels of LDL pose a heightened risk factor for vascular disease. -- Wikipedia |
Synonyms |
- (+)-ent-Cholesterol
- (-)-Cholesterol
- (20bFH)-cholest-5-en-3b-ol
- (3b)-cholest-5-en-3-ol
- (3beta)-Cholest-5-en-3-ol
- 20-epi-cholesterol
- 20-iso-cholesterol
- 20bFH-cholest-5-en-3b-ol
- 3beta-Hydroxycholest-5-ene
- 5-Cholesten-3B-ol
- 5-Cholesten-3beta-ol
- 5:6-Cholesten-3-ol
- 5:6-Cholesten-3beta-ol
- Cholest-5-en-3-ol
- Cholest-5-en-3beta-ol
- Cholesterin
- Cholesterine
- Cholesterol
- Cholesterol base H
- Cholesteryl alcohol
- Cholestrin
- Cholestrol
- Cordulan
- Dastar
- Dusoline
- Dusoran
- Dythol
- Epicholesterol
- Fancol CH
- Hydrocerin
- Kathro
- Lanol
- Liquid crystal CN/9
- Nimco cholesterol base H
- Nimco cholesterol base No. 712
- Super hartolan
- Tegolan
- cholest-5-en-3b-ol
- epicholesterin
|
Chemical IUPAC Name |
10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
Chemical Formula |
C27H46O |
Chemical Structure |
 |
Chemical Taxonomy |
Kingdom |
|
Super Class |
- Cholesterols and derivatives
|
Class |
- Steroids and Steroid Derivatives
|
Sub Class |
|
Family |
|
Species |
- secondary alcohol; alkene
|
Biofunction |
- Component of Bile acid biosynthesis; Component of C21-Steroid hormone metabolism
|
Application |
— |
Source |
|
|
Average Molecular Weight |
386.654 |
Monoisotopic Molecular Weight |
386.354858 |
Isomeric SMILES |
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(O)CC[C@]4(C)[C@H]3CC[C@]12C |
Canonical SMILES |
CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
KEGG Compound ID |
C00187  |
BioCyc ID |
CHOLESTEROL  |
BiGG ID |
34183  |
Wikipedia Link |
Cholesterol  |
METLIN ID |
163  |
PubChem Compound |
5997  |
PubChem Substance |
629186  |
ChEBI ID |
16113  |
CAS Registry Number |
57-88-5 |
InChI Identifier |
InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21?,22+,23-,24+,25+,26+,27-/m1/s1 |
Synthesis Reference |
Zhu, Yongming; Qin, Liena; Liu, Rui. Simple method for synthesis cholesterol from Diosgenin. Faming Zhuanli Shenqing Gongkai Shuomingshu (2006), 9 pp. |
Melting Point (Experimental) |
148 oC |
Experimental Water Solubility |
9.5e-05 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]
Source: PhysProp
|
Predicted Water Solubility |
2.79e-05 mg/mL [Predicted by ALOGPS]
Calculated using ALOGPS
|
Physiological Charge |
0 |
State |
Solid |
Experimental LogP/Hydrophobicity |
Not Available
Source: PhysProp
|
Predicted LogP/Hydrophobicity |
7.02 [Predicted by ALOGPS]; 8.2 [Predicted by PubChem via XLOGP]; 8.74 [MEYLAN,WM & HOWARD,PH (1995)]
Calculated using ALOGPS
|
Material Safety Data Sheet (MSDS) |
|
MOL File |
Show |
SDF File |
Show |
PDB File |
Show |
2D Structure |
|
3D Structure |
|
Experimental PDB ID |
1LRI  |
Experimental PDB File |
Show |
Experimental PDB Structure |
|
Experimental 1H NMR Spectrum |
Download Spectrum Download FID (Varian) Show Experimental Conditions  |
Experimental 13C NMR Spectrum |
Not Available |
Experimental 13C HSQC Spectrum |
Download Spectrum Download FID (Bruker) Show Experimental Conditions  |
Predicted 1H NMR Spectrum |
Show Image Show Peaklist
|
Predicted 13C NMR Spectrum |
Show Image Show Peaklist
|
Mass Spectrum |
Not Available |
Simplified TOCSY Spectrum |
Not Available |
BMRB Spectrum |
Not Available |
Cellular Location |
- Membrane
- Cytoplasm
- endoplasmic reticulum
- Extracellular
- golgi apparatus
- lysosome
- mitochondria
|
Biofluid Location |
|
Tissue Location |
Tissue |
References |
All Tissues |
— |
|
Concentrations (Normal) |
Biofluid |
Breast_Milk |
Value |
101.383 uM |
Age |
N/A |
Sex |
N/A |
Condition |
Normal |
Comments |
defatted milk/saponified. |
References |
|
Biofluid |
Breast_Milk |
Value |
51.726 uM |
Age |
N/A |
Sex |
N/A |
Condition |
Normal |
Comments |
Milk, Skim. |
References |
|
Biofluid |
Breast_Milk |
Value |
134.487 uM |
Age |
N/A |
Sex |
N/A |
Condition |
Normal |
Comments |
Milk, Partly Skimmed, 1% fat. |
References |
|
Biofluid |
Breast_Milk |
Value |
268.974 uM |
Age |
N/A |
Sex |
N/A |
Condition |
Normal |
Comments |
Milk, whole, 3.3% fat. |
References |
|
Biofluid |
Breast_Milk |
Value |
51.726 uM |
Age |
N/A |
Sex |
N/A |
Condition |
Normal |
Comments |
Milk, Skim. |
References |
|
Biofluid |
Breast_Milk |
Value |
129.315 uM |
Age |
N/A |
Sex |
N/A |
Condition |
Normal |
Comments |
Milk, fluid, partly skimmed, 1% milkfat. |
References |
|
Biofluid |
Breast_Milk |
Value |
206.903 uM |
Age |
N/A |
Sex |
N/A |
Condition |
Normal |
Comments |
Milk, fluid, partly skimmed, 2% milkfat. |
References |
|
Biofluid |
Breast_Milk |
Value |
258.629 uM |
Age |
N/A |
Sex |
N/A |
Condition |
Normal |
Comments |
Pasteurized. Milk, whole, pasteurized, homogenized, 3.3% milkfat. |
References |
|
Biofluid |
Breast_Milk |
Value |
362.0808 uM |
Age |
N/A |
Sex |
N/A |
Condition |
Normal |
Comments |
Milk, fluid, whole, producer, 3.7% milkfat. |
References |
|
Biofluid |
Breast_Milk |
Value |
266.738 uM |
Age |
NA |
Sex |
NA |
Condition |
Normal |
Comments |
Cow reduced fat milk (2% fat) with added vitamin A |
References |
|
Biofluid |
Breast_Milk |
Value |
133.369 uM |
Age |
NA |
Sex |
NA |
Condition |
Normal |
Comments |
Cow reduced fat milk (1% fat) with added vitamin A |
References |
|
Biofluid |
Breast_Milk |
Value |
53.563 uM |
Age |
NA |
Sex |
NA |
Condition |
Normal |
Comments |
Cow skim milk with added vitamin A |
References |
|
Biofluid |
Breast_Milk |
Value |
266.738 uM |
Age |
NA |
Sex |
NA |
Condition |
Normal |
Comments |
Cow whole milk (3.25% fat) |
References |
|
|
Concentrations (Abnormal) |
Not Available |
Pathway Names |
- Bile Acid Biosynthesis
- C21 Steroid Hormone Metabolism
- Steroid Biosynthesis
|
HMDB Pathways |
Name
|
Bile Acid Biosynthesis
|
Image
|
Show  |
Name
|
C21 Steroid Hormone Metabolism
|
Image
|
Show  |
Name
|
Steroid Biosynthesis
|
Image
|
Show  |
|
KEGG Pathways |
Name
|
Bile Acid Biosynthesis
|
Image
|
Show  |
Name
|
C21 Steroid Hormone Metabolism
|
Image
|
Show  |
Name
|
Steroid Biosynthesis
|
Image
|
Show  |
|
SimCell Pathways |
Name
|
Bile Acid Biosynthesis
|
Image
|
Show  |
Graph
|
|
SBML
|
|
Name
|
C21 Steroid Hormone Metabolism
|
Image
|
Show  |
Graph
|
|
SBML
|
|
Name
|
Steroid Biosynthesis
|
Image
|
Show  |
Graph
|
|
SBML
|
|
|
General References |
- Wikipedia

|
Metabolic Enzymes |
- Cholesterol side-chain cleavage enzyme, mitochondrial
- 7-dehydrocholesterol reductase
- Translocator protein
- Bile acid receptor
- Apolipoprotein A-I
- SCARB1 protein
- Cystic fibrosis transmembrane conductance regulator
- Sterol regulatory element-binding protein cleavage-activating protein
- StAR-related lipid transfer protein 5
- APOM protein
- Steroidogenic acute regulatory protein, mitochondrial
- Apolipoprotein E
- Apolipoprotein E
- Scavenger receptor class B member 1
- Na(+)/H(+) exchange regulatory cofactor NHE-RF3
|
Enzyme 1
[top]
|
Enzyme 1 ID |
53 |
Enzyme 1 Name |
Cholesterol side-chain cleavage enzyme, mitochondrial |
Enzyme 1 Synonyms |
- Cytochrome P450 11A1
- CYPXIA1
- P450(scc)
- Cholesterol desmolase
|
Enzyme 1 Gene Name |
CYP11A1 |
Enzyme 1 Protein Sequence |
>Cholesterol side-chain cleavage enzyme, mitochondrial
MLARGLPLRSALVKACPPILSTVGEGWGHHRVGTGEGAGISTKTPRPYSEIPSPGDNGWL
NLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPER
YDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVS
LLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKM
FHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGI
LYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARR
QAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYA
MGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE
NFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA |
Enzyme 1 Number of Residues |
520 |
Enzyme 1 Molecular Weight |
60332.4 |
Enzyme 1 Theoretical pI |
9.15 |
Enzyme 1 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 1 General Function |
Secondary metabolites biosynthesis, transport and catabolism |
Enzyme 1 Specific Function |
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone |
Enzyme 1 Pathways |
- Lipid metabolism
- C21-steroid hormone metabolism
|
Enzyme 1 Reactions |
Not Available |
Enzyme 1 Pfam Domain Function |
|
Enzyme 1 Signals |
|
Enzyme 1 Transmembrane Regions |
|
Enzyme 1 Essentiality |
Not Available |
Enzyme 1 GenBank ID Protein |
162951  |
Enzyme 1 UniProtKB/Swiss-Prot ID |
P00189  |
Enzyme 1 UniProtKB/Swiss-Prot Entry Name |
CP11A_BOVIN  |
Enzyme 1 PDB ID |
Not Available |
Enzyme 1 Cellular Location |
Not Available |
Enzyme 1 Gene Sequence |
>1563 bp
.AGCAGCAGCTGTGGGGGCAGCATGCTAGCAAGGGGGCTTCCCCTCCGCTCAGCCCTGGT
CAAAGCCTGCCCACCCATCCTGAGCACAGTGGGGGAGGGCTGGGGCCACCACAGGGTGGG
CACTGGAGAGGGAGCTGGCATCTCCACAAAGACCCCTCGCCCCTACAGTGAGATCCCCTC
CCCTGGTGACAATGGCTGGCTTAACCTCTACCATTTCTGGAGGGAGAAGGGCTCACAGAG
AATCCACTTTCGCCACATCGAGAACTTCCAGAAGTATGGCCCCATTTACAGGGAGAAGCT
TGGCAATTTGGAGTCAGTTTATATCATTCACCCTGAAGACGTGGCCCATCTCTTCAAGTT
CGAGGGATCCTACCCAGAGAGATATGACATCCCGCCCTGGCTGGCCTATCACCGATATTA
TCAGAAACCCATTGGAGTCCTGTTTAAGAAGTCAGGAACCTGGAAGAAAGACCGGGTGGT
CCTGAACACGGAGGTGATGGCTCCAGAGGCAATAAAGAACTTCATCCCACTGCTGAATCC
AGTGTCTCAGGACTTCGTCAGCCTCCTGCACAAGCGCATCAAGCAGCAGGGCTCCGGAAA
GTTTGTAGGGGACATCAAGGAAGACCTGTTTCACTTTGCCTTTGAGTCCATCACCAATGT
CATGTTTGGGGAGCGCCTGGGGATGCTGGAGGAGACAGTGAACCCCGAGGCCCAGAAGTT
CATTGATGCCGTCTACAAGATGTTCCACACCAGTGTCCCTCTGCTCAACGTCCCTCCAGA
ACTGTACCGTCTATTCAGAACCAAGACTTGGAGGGACCATGTAGCCGCATGGGACACAAT
TTTCAATAAAGCTGAAAAATACACTGAGATCTTCTACCAGGACCTGAGACGGAAAACAGA
ATTTAGGAATTACCCAGGCATCCTCTACTGCCTCCTGAAAAGTGAGAAGATGCTCTTGGA
GGATGTCAAGGCCAATATTACGGAGATGCTGGCAGGGGGTGTGAACACGACATCCATGAC
ATTGCAATGGCACTTGTACGAGATGGCACGCAGCCTGAATGTGCAGGAGATGCTGCGGGA
GGAGGTTCTGAATGCCCGACGCCAGGCAGAGGGAGACATAAGCAAGATGCTGCAAATGGT
CCCACTTCTCAAAGCTAGCATCAAGGAGACGCTGAGACTCCACCCCATCTCCGTGACCCT
GCAGAGATACCCTGAAAGTGACTTGGTTCTTCAAGATTACCTGATTCCTGCCAAGACACT
GGTGCAAGTGGCCATCTATGCCATGGGCCGAGACCCTGCCTTCTTCTCCAGTCCGGACAA
GTTTGACCCAACCAGGTGGCTGAGTAAAGACAAAGACCTCATCCACTTCCGGAACCTGGG
CTTTGGCTGGGGAGTGCGGCAGTGCGTGGGCCGGCGGATCGCCGAGCTGGAGATGACCCT
CTTCCTCATCCACATTCTGGAGAACTTCAAGGTTGAAATGCAGCATATCGGTGACGTGGA
CACCATATTCAACCTCATCCTGACGCCGGACAAGCCCATCTTCCTTGTCTTCCGCCCCTT
CAA |
Enzyme 1 GenBank Gene ID |
K02130  |
Enzyme 1 GeneCard ID |
CYP11A1  |
Enzyme 1 GenAtlas ID |
Not Available |
Enzyme 1 HGNC ID |
Not Available |
Enzyme 1 Chromosome Location |
Chromosome:1 |
Enzyme 1 Locus |
15q23-q24 |
Enzyme 1 SNPs |
SNPJam Report  |
Enzyme 1 General References |
- [PubMed
]
|
Enzyme 1 Metabolite References |
Not Available |
Enzyme 2
[top]
|
Enzyme 2 ID |
910 |
Enzyme 2 Name |
7-dehydrocholesterol reductase |
Enzyme 2 Synonyms |
- 7-DHC reductase
- Sterol Delta(7)-reductase
|
Enzyme 2 Gene Name |
DHCR7 |
Enzyme 2 Protein Sequence |
>7-dehydrocholesterol reductase
MAAKSQPSAPKTKSTSGLTNGNAAAQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYGCSLTVPVADLATGRARLADIWARTPPVTAKAAQIYTAWVTLQVLLYMLLPDFCHK
FLPGYVGGVQEGAVTPAGAVNKYEINGLQAWLLTHLLWFANAHLLGWFSPTIIFDNWIPL
LWCANILGYTVSTFAMVKGYLFPTDARECKFTGNFFYNYMMGVEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQQELYGHVTNSMVLVNILQAIYVLDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLPTYYALGVLLLGLLGYYIFRMTNHQKDL
FRRTDGRCLIWGRKPKAIECSYTSADGQRHHSKLLVSGFWGVARHFNYTGDLMGSLAYCL
ACGGGHLLPYFYIIFMAILLTHRCLRDEHRCANKYGRDWEHYTAAVPYRLLPGIF |
Enzyme 2 Number of Residues |
475 |
Enzyme 2 Molecular Weight |
54270.7 |
Enzyme 2 Theoretical pI |
8.53 |
Enzyme 2 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 2 General Function |
Involved in 7-dehydrocholesterol reductase activity |
Enzyme 2 Specific Function |
Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) |
Enzyme 2 Pathways |
- Steroid biosynthesis
- cholesterol biosynthesis
|
Enzyme 2 Reactions |
Not Available |
Enzyme 2 Pfam Domain Function |
|
Enzyme 2 Signals |
|
Enzyme 2 Transmembrane Regions |
- 40-60
151-173
178-200
266-286
306-326
331-351
420-440
|
Enzyme 2 Essentiality |
Not Available |
Enzyme 2 GenBank ID Protein |
59858215  |
Enzyme 2 UniProtKB/Swiss-Prot ID |
Q5E9J5  |
Enzyme 2 UniProtKB/Swiss-Prot Entry Name |
DHCR7_BOVIN  |
Enzyme 2 PDB ID |
Not Available |
Enzyme 2 Cellular Location |
Not Available |
Enzyme 2 Gene Sequence |
>1428 bp
ATGGCTGCGAAGTCCCAGCCCAGCGCCCCTAAAACCAAGAGCACCAGCGGCCTCACCAAC
GGCAACGCTGCAGCCCAAGGCCAGTGGGGCCGAGCCTGGGAGGTGGACTGGTTTTCCCTG
GCGAGCGTCATCTTCCTGCTGCTGTTTGCGCCCTTCATCGTGTACTACTTCATCATGGCC
TGCGACCAGTACGGCTGCTCCCTGACAGTGCCCGTGGCGGACCTCGCCACTGGGCGGGCT
CGGCTCGCCGACATCTGGGCCAGGACGCCGCCCGTGACCGCAAAGGCGGCCCAGATCTAC
ACAGCATGGGTCACGCTCCAGGTGCTTCTGTACATGCTGCTTCCTGACTTCTGCCACAAG
TTTCTTCCGGGCTACGTGGGGGGCGTTCAGGAGGGCGCCGTGACTCCCGCAGGAGCCGTC
AACAAGTATGAGATCAACGGCCTGCAGGCCTGGCTCCTCACGCACCTCCTGTGGTTCGCC
AACGCCCACCTCCTCGGCTGGTTCTCCCCCACCATCATTTTCGACAACTGGATCCCGCTG
CTCTGGTGTGCCAACATCCTGGGCTACACCGTCTCCACCTTCGCCATGGTCAAGGGCTAC
CTCTTCCCCACTGACGCCCGGGAATGCAAATTCACGGGCAATTTCTTTTACAACTACATG
ATGGGCGTTGAGTTTAACCCCCGAATTGGGAAGTGGTTTGACTTCAAGCTCTTCTTCAAT
GGACGCCCCGGGATCGTCGCCTGGACCCTCATCAACCTGTCCTTTGCAGCCAAGCAGCAG
GAGCTCTACGGCCACGTGACCAACTCCATGGTCTTGGTCAACATCCTGCAGGCCATCTAC
GTGCTGGACTTCTTCTGGAACGAAACCTGGTACCTGAAAACCATCGACATCTGCCACGAC
CACTTTGGGTGGTACCTGGGCTGGGGGGACTGCGTCTGGCTGCCATACCTGTACACGCTG
CAGGGCCTGTACCTGGTGTACCACCCCGTGCAGCTGCCCACCTACTACGCGCTGGGCGTC
CTGCTCCTGGGCCTGCTCGGCTACTACATCTTCCGGATGACCAACCACCAGAAGGACCTC
TTCCGCCGCACGGACGGGCGCTGCCTGATCTGGGGCAGGAAGCCCAAGGCCATCGAGTGC
TCCTACACATCAGCCGACGGGCAGAGACACCACAGCAAGCTGCTGGTCTCGGGCTTCTGG
GGCGTGGCCCGCCACTTCAACTACACGGGTGACCTGATGGGCAGCCTGGCGTACTGCCTG
GCCTGCGGCGGCGGCCACCTCCTGCCCTACTTCTACATCATCTTCATGGCCATCCTGCTG
ACCCACCGCTGCCTCCGGGACGAGCACCGCTGTGCCAACAAGTACGGCCGCGACTGGGAG
CACTACACGGCCGCCGTGCCGTACCGCCTGCTCCCTGGCATCTTCTAG |
Enzyme 2 GenBank Gene ID |
BT020925  |
Enzyme 2 GeneCard ID |
DHCR7  |
Enzyme 2 GenAtlas ID |
Not Available |
Enzyme 2 HGNC ID |
Not Available |
Enzyme 2 Chromosome Location |
Chromosome:1 |
Enzyme 2 Locus |
11q13.2-q13.5 |
Enzyme 2 SNPs |
SNPJam Report  |
Enzyme 2 General References |
- [PubMed
]
|
Enzyme 2 Metabolite References |
Not Available |
Enzyme 3
[top]
|
Enzyme 3 ID |
1500 |
Enzyme 3 Name |
Translocator protein |
Enzyme 3 Synonyms |
- Peripheral-type benzodiazepine receptor
- PBR
- PKBS
- Isoquinoline-binding protein
- IBP
|
Enzyme 3 Gene Name |
TSPO |
Enzyme 3 Protein Sequence |
>Translocator protein
MAPPWVPAVGFTLLPSLGGFLGAQYTRGEGFRWYASLQKPPWHPPRWILAPIWGTLYSAM
GYGSYMIWKELGGFSKEAVVPLGLYAGQLALNWAWPPLFFGTRQMGWALVDLLLTGGMAA
ATAMAWHQVSPPAACLLYPYLAWLAFAGMLNYRMWQDNQVRRSGRRLSE |
Enzyme 3 Number of Residues |
169 |
Enzyme 3 Molecular Weight |
18927.0 |
Enzyme 3 Theoretical pI |
9.94 |
Enzyme 3 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 3 General Function |
Signal transduction mechanisms |
Enzyme 3 Specific Function |
Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity) |
Enzyme 3 Pathways |
Not Available |
Enzyme 3 Reactions |
Not Available |
Enzyme 3 Pfam Domain Function |
|
Enzyme 3 Signals |
|
Enzyme 3 Transmembrane Regions |
- 6-26
47-67
80-100
106-126
135-155
|
Enzyme 3 Essentiality |
Not Available |
Enzyme 3 GenBank ID Protein |
163489  |
Enzyme 3 UniProtKB/Swiss-Prot ID |
P30535  |
Enzyme 3 UniProtKB/Swiss-Prot Entry Name |
TSPO_BOVIN  |
Enzyme 3 PDB ID |
Not Available |
Enzyme 3 Cellular Location |
Not Available |
Enzyme 3 Gene Sequence |
>510 bp
ATGGCCCCACCCTGGGTGCCTGCCGTGGGCTTCACGCTGTTGCCCAGTCTGGGGGGCTTC
CTGGGTGCCCAGTACACCCGCGGAGAGGGTTTCCGCTGGTACGCCAGCCTGCAGAAGCCC
CCGTGGCACCCGCCCCGCTGGATTCTGGCTCCCATCTGGGGCACACTCTACTCGGCCATG
GGGTATGGTTCCTACATGATCTGGAAAGAGCTGGGGGGCTTCTCGAAGGAGGCGGTGGTT
CCCCTGGGCCTCTACGCTGGGCAGCTGGCTCTGAACTGGGCATGGCCTCCCCTCTTCTTC
GGCACTCGACAAATGGGCTGGGCCTTGGTGGATCTCCTGCTGACTGGCGGCATGGCAGCA
GCCACGGCCATGGCCTGGCACCAGGTGAGCCCGCCGGCTGCCTGCCTGCTGTACCCGTAC
CTGGCCTGGCTGGCCTTTGCCGGCATGCTCAACTACCGCATGTGGCAGGACAACCAGGTC
CGGAGGAGTGGCCGGCGGCTCTCGGAATGA |
Enzyme 3 GenBank Gene ID |
M64520  |
Enzyme 3 GeneCard ID |
TSPO  |
Enzyme 3 GenAtlas ID |
Not Available |
Enzyme 3 HGNC ID |
Not Available |
Enzyme 3 Chromosome Location |
Chromosome:2 |
Enzyme 3 Locus |
22q13.31 |
Enzyme 3 SNPs |
SNPJam Report  |
Enzyme 3 General References |
- [PubMed
]
|
Enzyme 3 Metabolite References |
Not Available |
Enzyme 4
[top]
|
Enzyme 4 ID |
1586 |
Enzyme 4 Name |
Bile acid receptor |
Enzyme 4 Synonyms |
- Farnesoid X-activated receptor
- Farnesol receptor HRR-1
- Nuclear receptor subfamily 1 group H member 4
|
Enzyme 4 Gene Name |
NR1H4 |
Enzyme 4 Protein Sequence |
>Bile acid receptor
MVMQFQELENPVQISPCHSHTSSGFDMEVMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYN
NVQFPQVQPQISSSSYYSNVGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVVEIPITK
KARLGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQAIHEDSEGRDLR
QVTSTTKSCREKTELTPDQQNLLHYIMDSYSKQRMPQEITNKFLKEEFSAEENFIILTEM
ATSHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFSKKLPAGHTDLLEE
RIRKSGISDEYITPMFSFYKSVAELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEP
LLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHADMLMSWRVNDHKFTPLLCEIWD
VQ |
Enzyme 4 Number of Residues |
482 |
Enzyme 4 Molecular Weight |
55459.2 |
Enzyme 4 Theoretical pI |
6.77 |
Enzyme 4 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 4 General Function |
Involved in sequence-specific DNA binding |
Enzyme 4 Specific Function |
Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus |
Enzyme 4 Pathways |
Not Available |
Enzyme 4 Reactions |
Not Available |
Enzyme 4 Pfam Domain Function |
|
Enzyme 4 Signals |
|
Enzyme 4 Transmembrane Regions |
|
Enzyme 4 Essentiality |
Not Available |
Enzyme 4 GenBank ID Protein |
74267703  |
Enzyme 4 UniProtKB/Swiss-Prot ID |
Q3SZL0  |
Enzyme 4 UniProtKB/Swiss-Prot Entry Name |
NR1H4_BOVIN  |
Enzyme 4 PDB ID |
1OSH  |
Enzyme 4 PDB File |
Show |
Enzyme 4 3D Structure |
|
Enzyme 4 Cellular Location |
Not Available |
Enzyme 4 Gene Sequence |
>1449 bp
ATGGTAATGCAGTTTCAGGAGTTAGAAAATCCAGTTCAAATCAGTCCTTGTCACAGCCAC
ACATCCTCAGGATTTGACATGGAAGTGATGAGCATGAAGCCCGCTAAAGGTGTACTAACA
GAGCAAGTGGCAGGTCCTCTGGGACAGAATCTGGAAGTGGAACCGTACTCACAATACAAC
AACGTTCAGTTTCCCCAAGTTCAACCACAGATTTCCTCTTCTTCCTATTATTCCAATGTG
GGTTTCTATCCCCAGCAGCCTGAAGAGTGGTACTCTCCTGGAATATATGAACTCAGGCGA
ATGCCTGCTGAGACTCTCTATCAGGGAGAGACTGAGGTAGTGGAGATTCCTATAACCAAG
AAGGCCCGACTGGGAGCATCAGCAGGGAGAATCAAAGGGGATGAGCTATGTGTTGTCTGT
GGAGACCGAGCATCTGGATATCACTATAACGCCCTGACCTGTGAGGGATGCAAAGGTTTC
TTCAGAAGAAGCATTACCAAAAACGCTGTGTACAAGTGTAAAAACGGGGGCAACTGTGTG
ATGGACATGTACATGCGAAGGAAGTGCCAAGAGTGTCGACTAAGGAAATGCAAAGAAATG
GGAATGTTGGCTGAATGCTTGTTAACTGAAATTCAGTGTAAATCTAAACGACTGAGAAAA
AACGTGAAGCAGCATGCAGATCAGGCCATCCATGAAGACAGTGAAGGACGTGACCTGCGA
CAAGTGACCTCGACAACTAAGTCATGCAGGGAGAAAACTGAACTCACCCCAGATCAACAG
AATCTTCTTCATTATATTATGGATTCATATAGCAAGCAGAGGATGCCTCAGGAAATAACA
AATAAATTTTTAAAAGAAGAATTCAGCGCAGAAGAAAATTTTATCATTTTAACTGAAATG
GCTACCAGTCATGTACAGGTTCTTGTAGAATTCACAAAAAAACTTCCAGGATTTCAGACA
TTGGACCATGAAGATCAGATTGCCTTGCTGAAAGGGTCTGCAGTTGAAGCGATGTTTCTC
CGTTCAGCTGAGATTTTCAGTAAGAAACTTCCAGCTGGACATACTGACCTACTGGAAGAA
AGAATTCGAAAGAGTGGTATCTCTGATGAATATATAACACCTATGTTTAGCTTTTATAAA
AGTGTTGCTGAATTGAAAATGACTCAAGAAGAGTATGCTCTGCTTACAGCTATTGTTATC
CTCTCTCCAGATAGACAATACATAAAGGACAGAGAGGCAGTAGAGAAGCTTCAGGAACCA
CTGCTTGATGTGCTACAAAAGTTATGTAAGATTCATCAGCCTGAGAATCCTCAACATTTT
GCCTGTCTTCTGGGTCGCCTGACTGAGTTGAGGACATTCAACCATCACCACGCAGACATG
CTTATGTCATGGAGAGTGAATGACCACAAGTTTACCCCACTTCTCTGTGAAATCTGGGAT
GTGCAGTGA |
Enzyme 4 GenBank Gene ID |
BC102805  |
Enzyme 4 GeneCard ID |
NR1H4  |
Enzyme 4 GenAtlas ID |
Not Available |
Enzyme 4 HGNC ID |
Not Available |
Enzyme 4 Chromosome Location |
Chromosome:1 |
Enzyme 4 Locus |
12q23.1 |
Enzyme 4 SNPs |
SNPJam Report  |
Enzyme 4 General References |
Not Available |
Enzyme 4 Metabolite References |
Not Available |
Enzyme 5
[top]
|
Enzyme 5 ID |
2125 |
Enzyme 5 Name |
Apolipoprotein A-I |
Enzyme 5 Synonyms |
- Apo-AI
- ApoA-I
|
Enzyme 5 Gene Name |
APOA1 |
Enzyme 5 Protein Sequence |
>Apolipoprotein A-I
MKAVVLTLAVLFLTGSQARHFWQQDDPQSSWDRVKDFATVYVEAIKDSGRDYVAQFEASA
LGKQLNLKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETASLRQEMHKDLEEVKQKV
QPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARAHVE
TLRQQLAPYSDDLRQRLTARLEALKEGGGSLAEYHAKASEQLKALGEKAKPVLEDLRQGL
LPVLESLKVSILAAIDEASKKLNAQ |
Enzyme 5 Number of Residues |
265 |
Enzyme 5 Molecular Weight |
30276.1 |
Enzyme 5 Theoretical pI |
5.77 |
Enzyme 5 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 5 General Function |
Cell cycle control, cell division, chromosome partitioning |
Enzyme 5 Specific Function |
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility |
Enzyme 5 Pathways |
Not Available |
Enzyme 5 Reactions |
Not Available |
Enzyme 5 Pfam Domain Function |
|
Enzyme 5 Signals |
|
Enzyme 5 Transmembrane Regions |
|
Enzyme 5 Essentiality |
Not Available |
Enzyme 5 GenBank ID Protein |
162678  |
Enzyme 5 UniProtKB/Swiss-Prot ID |
P15497  |
Enzyme 5 UniProtKB/Swiss-Prot Entry Name |
APOA1_BOVIN  |
Enzyme 5 PDB ID |
Not Available |
Enzyme 5 Cellular Location |
Not Available |
Enzyme 5 Gene Sequence |
>798 bp
ATGAAAGCCGTGGTGCTGACCTTGGCTGTGCTCTTCCTGACGGGGAGCCAGGCTCGGCAT
TTCTGGCAGCAAGATGACCCCCAGTCATCCTGGGATCGGGTGAAGGATTTTGCCACCGTG
TATGTGGAAGCAATCAAGGATAGTGGCAGAGACTATGTGGCCCAATTCGAAGCCTCCGCT
TTGGGAAAACAGCTCAACCTGAAACTCCTGGACAACTGGGACACCCTGGCCAGCACGTTG
TCCAAAGTGCGTGAACAGCTGGGCCCAGTGACCCAGGAGTTCTGGGACAACCTGGAAAAG
GAGACCGCGTCGCTGAGGCAGGAGATGCACAAGGACCTGGAGGAGGTGAAGCAGAAGGTG
CAGCCCTACCTGGACGAGTTCCAGAAGAAGTGGCACGAGGAGGTGGAGATCTACCGCCAG
AAGGTGGCGCCGCTGGGCGAGGAGTTTCGCGAGGGCGCGCGCCAGAAGGTGCAGGAGCTG
CAGGACAAGCTGAGCCCTCTGGCCCAGGAGCTCCGCGACCGCGCGCGCGCCCACGTGGAG
ACGCTGCGGCAGCACGTGGCGCCCTACAGCGACGACCTGCGCCAGCGGCTGACCGCGCGC
CTGGAGGCGCTCAAGGAGGGCGGCGGCAGCCTGGCCGAGTACCACGCCAAGGCCAGCGAG
CAGCTGAAGGCGCTGGGCGAGAAGGCCAAGCCGGTGCTGGAGGACCTCCGCCAGGGCCTG
CTGCCCGTGCTGGAGAGCCTCAAGGTCAGCATCCTGGCCGCCATAGACGAGGCCTCCAAG
AAGCTGAACGCCCAGTGA |
Enzyme 5 GenBank Gene ID |
M35870  |
Enzyme 5 GeneCard ID |
APOA1  |
Enzyme 5 GenAtlas ID |
Not Available |
Enzyme 5 HGNC ID |
Not Available |
Enzyme 5 Chromosome Location |
Chromosome:1 |
Enzyme 5 Locus |
11q23-q24 |
Enzyme 5 SNPs |
SNPJam Report  |
Enzyme 5 General References |
- [PubMed
]
|
Enzyme 5 Metabolite References |
Not Available |
Enzyme 6
[top]
|
Enzyme 6 ID |
2126 |
Enzyme 6 Name |
SCARB1 protein |
Enzyme 6 Synonyms |
Not Available |
Enzyme 6 Gene Name |
SCARB1 |
Enzyme 6 Protein Sequence |
>SCARB1 protein
MGNLSRARRVTAALGFIGLLFAVLGIIMIVMVPSIIKQQVLKNVRIDPNSLSFNMWKEIP
VPFYLSVYFFNIVNPEGIIQGQKPQVQEHGPYVYREFRHKSNITFNNNDTVSFLEYRSYQ
FQPDKSRGQESDYIVMPNILVLSASMMMENRPGLLKLMMTLAFSTLGQRAFMNRTVGEIM
WGYDDPLIHLINQYFPNSLPFKGKFGLFAELNNSDSGLFTVFTGVKNFSRIHLVDKWNGV
SKVNYWHSDQCNMINGTSGQMWAPFMTPESSLEFYSPEACRSMKLVYKEQGVFGGIPTFR
FVAPSTLFANGSVYPPNEGFCPCRESGIQNVSTCRFNAPLFLSHPHFYNADPVLAEAVSG
LHPNPKEHSLFLDIHPVTGIPMNCSVKLQLSLFVKSVKGIGQTGNIQPVVLPLMWFEESG
AMEGETLETFYIQLVLMPKVLHYAQYVLLALGCVLLLIPIIYQIRSQGSKDAISQPCLAT
QPDQLPSPYTPLLQDSLRGQPTSPKV |
Enzyme 6 Number of Residues |
506 |
Enzyme 6 Molecular Weight |
56915.7 |
Enzyme 6 Theoretical pI |
8.20 |
Enzyme 6 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 6 General Function |
Involved in high-density lipoprotein binding |
Enzyme 6 Specific Function |
Not Available |
Enzyme 6 Pathways |
Not Available |
Enzyme 6 Reactions |
Not Available |
Enzyme 6 Pfam Domain Function |
|
Enzyme 6 Signals |
|
Enzyme 6 Transmembrane Regions |
|
Enzyme 6 Essentiality |
Not Available |
Enzyme 6 GenBank ID Protein |
134025123  |
Enzyme 6 UniProtKB/Swiss-Prot ID |
A4IFC6  |
Enzyme 6 UniProtKB/Swiss-Prot Entry Name |
A4IFC6_BOVIN  |
Enzyme 6 PDB ID |
Not Available |
Enzyme 6 Cellular Location |
Not Available |
Enzyme 6 Gene Sequence |
>1521 bp
ATGGGCAACCTCTCTAGAGCGCGCCGGGTGACCGCGGCGCTGGGTTTCATCGGGCTCCTC
TTCGCCGTGCTGGGCATTATCATGATCGTGATGGTGCCCTCAATCATCAAGCAGCAGGTC
CTCAAGAATGTGCGCATCGACCCCAACAGCCTGTCTTTCAACATGTGGAAGGAAATCCCT
GTCCCCTTCTACCTCTCTGTCTACTTTTTCAACATCGTCAACCCTGAGGGGATCATCCAA
GGCCAGAAGCCACAGGTGCAGGAGCACGGGCCTTATGTGTACAGGGAGTTCAGGCACAAG
AGCAACATCACCTTCAACAACAATGACACGGTGTCCTTCCTGGAGTACCGCAGCTACCAG
TTCCAGCCGGATAAGTCCCGCGGCCAGGAGAGCGACTACATCGTCATGCCCAACATCCTG
GTCTTGAGTGCGTCAATGATGATGGAGAACAGGCCCGGGCTCTTGAAGCTGATGATGACC
TTGGCGTTCAGCACGCTTGGCCAGCGTGCCTTCATGAACCGCACTGTTGGCGAGATCATG
TGGGGCTATGATGACCCCTTAATCCACCTCATCAATCAGTACTTCCCAAACTCGCTCCCC
TTCAAGGGCAAGTTCGGCTTATTTGCTGAGCTCAACAACTCCGATTCTGGCCTCTTCACC
GTGTTCACAGGGGTCAAAAACTTCAGCAGGATCCATCTCGTGGACAAGTGGAATGGAGTC
AGCAAGGTCAACTATTGGCATTCCGATCAGTGCAACATGATTAACGGAACTTCCGGGCAG
ATGTGGGCACCATTTATGACCCCTGAATCCTCGCTGGAATTTTACAGCCCTGAGGCCTGC
CGGTCCATGAAGCTCGTCTACAAGGAGCAGGGGGTGTTTGGAGGCATCCCCACCTTTCGC
TTCGTGGCTCCCAGCACCTTATTTGCCAACGGGTCCGTCTACCCGCCCAACGAGGGCTTC
TGCCCCTGCCGGGAGTCCGGAATCCAAAACGTCAGCACCTGCAGGTTCAATGCGCCCTTG
TTTCTCTCCCATCCTCACTTCTACAACGCTGACCCAGTCCTGGCAGAGGCAGTGTCTGGC
CTCCATCCTAACCCAAAAGAACATTCCTTGTTCCTGGACATCCACCCGGTCACCGGAATC
CCCATGAACTGCTCTGTGAAACTGCAGCTGAGCCTCTTCGTTAAGTCTGTGAAAGGCATC
GGACAAACTGGGAACATCCAGCCAGTGGTCCTGCCGCTAATGTGGTTCGAAGAGAGTGGA
GCAATGGAGGGTGAGACCCTTGAGACGTTCTATATCCAGCTGGTGTTGATGCCCAAAGTG
CTACACTATGCCCAGTATGTGCTCCTTGCCCTGGGCTGCGTCCTACTGCTCATCCCCATC
ATCTACCAAATCCGGAGCCAAGGTTCCAAAGATGCCATCAGCCAGCCCTGTCTGGCCACT
CAGCCAGACCAACTTCCCAGCCCCTACACCCCGCTTCTTCAGGACTCGCTCCGTGGACAG
CCCACCAGTCCCAAAGTCTGA |
Enzyme 6 GenBank Gene ID |
BC134513  |
Enzyme 6 GeneCard ID |
SCARB1  |
Enzyme 6 GenAtlas ID |
Not Available |
Enzyme 6 HGNC ID |
Not Available |
Enzyme 6 Chromosome Location |
Chromosome:1 |
Enzyme 6 Locus |
12q24.31 |
Enzyme 6 SNPs |
SNPJam Report  |
Enzyme 6 General References |
Not Available |
Enzyme 6 Metabolite References |
Not Available |
Enzyme 7
[top]
|
Enzyme 7 ID |
2127 |
Enzyme 7 Name |
Cystic fibrosis transmembrane conductance regulator |
Enzyme 7 Synonyms |
Not Available |
Enzyme 7 Gene Name |
CFTR |
Enzyme 7 Protein Sequence |
>Cystic fibrosis transmembrane conductance regulator
LMCLARSVLSKAKILLLDEPSAHLDPITYQIIRRTLKQAFANCTVILS |
Enzyme 7 Number of Residues |
48 |
Enzyme 7 Molecular Weight |
5369.4 |
Enzyme 7 Theoretical pI |
9.46 |
Enzyme 7 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 7 General Function |
Involved in chloride channel activity |
Enzyme 7 Specific Function |
Not Available |
Enzyme 7 Pathways |
Not Available |
Enzyme 7 Reactions |
Not Available |
Enzyme 7 Pfam Domain Function |
Not Available |
Enzyme 7 Signals |
|
Enzyme 7 Transmembrane Regions |
|
Enzyme 7 Essentiality |
Not Available |
Enzyme 7 GenBank ID Protein |
6635455  |
Enzyme 7 UniProtKB/Swiss-Prot ID |
Q9TSX2  |
Enzyme 7 UniProtKB/Swiss-Prot Entry Name |
Q9TSX2_BOVIN  |
Enzyme 7 PDB ID |
Not Available |
Enzyme 7 Cellular Location |
Not Available |
Enzyme 7 Gene Sequence |
Not Available |
Enzyme 7 GenBank Gene ID |
AF201742  |
Enzyme 7 GeneCard ID |
CFTR  |
Enzyme 7 GenAtlas ID |
Not Available |
Enzyme 7 HGNC ID |
Not Available |
Enzyme 7 Chromosome Location |
Chromosome:7 |
Enzyme 7 Locus |
7q31.2 |
Enzyme 7 SNPs |
SNPJam Report  |
Enzyme 7 General References |
- [PubMed
]
|
Enzyme 7 Metabolite References |
Not Available |
Enzyme 8
[top]
|
Enzyme 8 ID |
2128 |
Enzyme 8 Name |
Sterol regulatory element-binding protein cleavage-activating protein |
Enzyme 8 Synonyms |
- SREBP cleavage-activating protein
- SCAP
|
Enzyme 8 Gene Name |
SCAP |
Enzyme 8 Protein Sequence |
>Sterol regulatory element-binding protein cleavage-activating protein
MTLTERLREKISQAFYNHGLFCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFTTP
VKDYSPPPLTSDHKPGEPNEQPEWYVGAPVAYIQQIFVKSSVSPWHKNLLAVDVFRSPLS
RAFQLVEEIRNHVLKDSSGTRSLEDVCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQN
DRERFHADPDIIRTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRLVSYTITLVF
QHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGIAELIPLVTTYIILFAYIY
FSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLEN
VLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIVLIGYFTLVPAIQEFCLF
AVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPPAKPVGRPTRFERQPTV
RPSMPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLR
TYLAAQVTEQSPLGEGALAPLPVPSGVLPASHPDPAFSIFPPDASKLPENQTLPGEPPEP
GGLAEGVHDSPAPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYVSLLPVIPVTLR
LNPREALEGRHPQDGRSAWPPPRPGQGGLWEAGPKGPGTAQAQRDLTLYKVAALGLASGI
VLVLLLLCLYRVLCPRNYGQPGAGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIE
CLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPHPGQRRDSGVGSGLETQETWERLSDGG
KGGPEEPGDSPPLRHRPRGPPPPALFGDQPDLTCLIDTNFSARPQLPEPAQPEPRYRAGR
RAQDSAGYDFSRLVQRVYQEGGMAPVHTPALRPPSPGPTFPLAPEDEAGFPPEKSCPSLA
WAPSTDGSIWSLELQGSLIVVGRSSGRLEVWDAIEGTLRCSSEEVSSGITALVFLDRRIV
AARLNGSLDFFSLETHTALSPLQFRGAPGRGSSPASPACSSSDRVACHLTHTVPCAHQKP
ITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGA
ICLWDVLTGSRVSHMFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKLYSIQQDLG
CGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCN
FGSELSLVYVPSVLEKLD |
Enzyme 8 Number of Residues |
1278 |
Enzyme 8 Molecular Weight |
139699.6 |
Enzyme 8 Theoretical pI |
7.10 |
Enzyme 8 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 8 General Function |
Not Available |
Enzyme 8 Specific Function |
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway |
Enzyme 8 Pathways |
Not Available |
Enzyme 8 Reactions |
Not Available |
Enzyme 8 Pfam Domain Function |
|
Enzyme 8 Signals |
|
Enzyme 8 Transmembrane Regions |
- 19-39
280-300
313-333
345-365
402-422
424-444
519-539
708-728
|
Enzyme 8 Essentiality |
Not Available |
Enzyme 8 GenBank ID Protein |
151556356  |
Enzyme 8 UniProtKB/Swiss-Prot ID |
A6QM06  |
Enzyme 8 UniProtKB/Swiss-Prot Entry Name |
SCAP_BOVIN  |
Enzyme 8 PDB ID |
Not Available |
Enzyme 8 Cellular Location |
Not Available |
Enzyme 8 Gene Sequence |
>3837 bp
ATGACCCTGACTGAAAGGCTGCGTGAGAAGATATCCCAGGCCTTCTACAACCATGGGCTG
TTCTGTGCGTCCTACCCCATCCCCATCATTCTCTTCACGGGGCTCTGCATCTTAGCCTGC
TGCTACCCACTGCTGAAGCTGCCCTTGCCAGGAACAGGACCTGTGGAATTCACCACTCCT
GTGAAAGATTACTCGCCCCCACCTCTGACCTCTGACCACAAGCCTGGAGAGCCCAATGAG
CAGCCAGAGTGGTACGTGGGGGCCCCGGTGGCTTATATCCAGCAGATATTTGTGAAATCT
TCCGTGTCTCCCTGGCACAAGAACCTCCTAGCAGTAGATGTGTTCCGCTCACCTCTGTCG
AGGGCATTCCAGCTGGTGGAGGAGATTCGGAACCACGTGCTGAAAGACAGCTCCGGGACC
AGGAGCCTGGAGGACGTGTGCCTGCAGGTGACTGACCTGCTGCCAGGCCTCAGGAAGCTC
CGCAACCTCCTGCCCGAGCATGGATGCCTGCTGCTCTCCCCCGGGAACTTCTGGCAGAAT
GACAGGGAGCGCTTCCACGCAGATCCCGACATCATCAGGACCATCCACCAGCACGAGCCC
AAAACCCTGCAGACCTCGGCCACACTCAAAGACCTGCTGTTTGGCGTCCCTGGGAAGTAC
AGCGGGGTGAGCCTGTACACCAGGAAGCGGCTGGTCTCATACACCATCACCCTGGTCTTC
CAGCACTACCACGCCAAGTTCCTGGGCAGCCTGCGGGCCCGCCTGATGCTCCTGCACCCC
AGCCCCAACTGCAGCCTCAGAGCAGAGAGCCTGGTCCATGTGCACTTCAAGGAGGAGATT
GGCATCGCTGAGCTCATCCCCCTGGTGACCACCTACATCATCCTGTTCGCCTACATCTAC
TTCTCCACACGCAAGATCGACATGGTCAAGTCCAAGTGGGGCCTGGCTCTGGCTGCCGTC
GTCACGGTGCTCAGCTCGCTGCTCATGTCTGTGGGGCTCTGCACACTCTTCGGCCTGACA
CCCACGCTCAATGGCGGGGAGATCTTCCCCTACCTGGTGGTGGTCATTGGGCTGGAGAAC
GTGCTGGTGCTCACCAAGTCCGTCGTCTCCACCCCGGTGGACCTCGAGGTGAAGCTGCGC
ATTGCCCAAGGCCTGAGCAGCGAGAGCTGGTCCATCATGAAGAACATGGCCACAGAGCTG
GGCATCGTCCTCATTGGCTACTTCACCCTAGTGCCTGCCATCCAGGAGTTCTGTCTTTTT
GCCGTCGTGGGGCTGGTGTCTGACTTTTTCCTTCAGATGCTGTTTTTCACCACTGTCCTG
TCCATTGACATTCGCCGGATGGAGCTGGCGGACCTGAACAAGCGGCTGCCCCCTGAGGCC
TGCCTGCCCCCAGCCAAGCCGGTGGGGCGGCCAACACGCTTTGAGCGGCAGCCGACTGTG
CGGCCATCCATGCCCCACACCATCACACTGCAGCCGTCCTCCTTCCGCAACCTGCGTCTC
CCCAAGCGGCTGCGTGTCATCTACTTCCTGGCCCGAACCCGCCTGGCACAGCGCCTCATC
ATGGCTGGCACGGTGGTGTGGATCGGCATCCTTGTGTACACGGACCCAGCTGGGCTGCGC
ACCTACCTGGCCGCCCAGGTAACGGAGCAGAGCCCGCTGGGCGAGGGTGCCCTGGCTCCT
CTGCCTGTGCCCAGTGGTGTGCTGCCTGCCAGCCACCCGGATCCTGCCTTTTCCATCTTC
CCGCCGGATGCCTCCAAGTTACCCGAGAACCAGACGTTGCCAGGGGAGCCGCCTGAGCCC
GGGGGTCTCGCCGAGGGCGTCCATGACAGCCCGGCCCCAGAGGTCACCTGGGGGCCCGAG
GACGAGGAGCTCTGGAGGAAACTGTCCTTCCGCCACTGGCCCACGCTCTTCAGCTATTAC
AACATCACACTGGCCAAGAGGTACGTCAGCCTGCTGCCTGTCATCCCCGTCACGCTCCGC
CTGAACCCGCGGGAGGCTCTGGAGGGCCGGCACCCTCAGGACGGCCGCAGCGCCTGGCCC
CCGCCCCGGCCCGGGCAGGGTGGGCTCTGGGAGGCCGGCCCCAAGGGGCCAGGCACGGCG
CAGGCGCAGAGAGACCTCACCCTGTACAAGGTGGCGGCACTTGGCCTGGCCTCAGGCATC
GTGCTTGTGCTGCTGCTGCTCTGCCTGTACCGTGTGCTCTGCCCGCGCAACTACGGGCAG
CCCGGCGCGGGGCCCGGCCGGCGGCGGCGGGGGGAGCTGCCCTGCGACGATTATGGCTAC
GCGCCCCCCGAGACGGAGATTGTGCCCCTGGTGCTGCGCGGGCACCTCATGGACATCGAG
TGTCTGGCCAGCGACGGGATGCTACTGGTGAGCTGTTGCCTGGCAGGCCACGTGTGTGTA
TGGGACGCGCAGACCGGAGACTGCCTCACCCGCATCCCGCACCCGGGGCAGCGGCGGGAC
AGCGGTGTTGGTAGCGGGCTGGAGACTCAGGAGACCTGGGAACGGCTGTCGGACGGCGGG
AAGGGTGGCCCGGAGGAGCCTGGGGACAGCCCTCCGCTGCGGCACCGGCCCCGGGGCCCT
CCACCCCCTGCCCTCTTTGGGGACCAGCCAGACCTCACCTGCTTGATTGACACCAACTTT
TCAGCGCGGCCACAGCTCCCCGAGCCGGCTCAGCCCGAGCCCCGGTACCGGGCGGGCCGC
CGTGCTCAAGACTCCGCAGGCTACGACTTCAGCCGCCTGGTGCAGCGCGTGTACCAGGAG
GGGGGCATGGCTCCCGTGCACACGCCAGCCCTGCGCCCACCCTCTCCCGGGCCCACGTTC
CCCCTGGCCCCTGAGGACGAGGCTGGCTTTCCTCCCGAGAAGAGCTGCCCGTCCCTCGCC
TGGGCCCCCAGCACAGATGGCTCCATCTGGAGTCTGGAGTTGCAGGGCAGCCTCATCGTG
GTGGGGCGGAGCAGTGGCCGGCTGGAGGTGTGGGACGCCATCGAGGGCACCCTGCGCTGC
AGCAGTGAGGAAGTGTCATCAGGCATCACGGCCCTCGTTTTCCTGGACAGAAGGATTGTG
GCCGCCCGACTCAATGGCTCCCTCGATTTCTTCTCTTTGGAGACCCACACTGCCCTCAGC
CCCCTGCAGTTCCGAGGGGCCCCGGGGCGGGGCAGTTCCCCTGCCTCCCCCGCGTGCAGC
AGCAGTGACAGGGTGGCTTGCCACCTGACCCACACCGTGCCCTGTGCACACCAGAAGCCC
ATCACAGCCCTGAAGGCCGCTGCCGGGCGCCTCGTGACTGGCAGCCAGGACCACACACTG
AGAGTGTTCCGCCTGGAGGATTCGTGCTGCCTCTTCACCCTGCAGGGCCACTCGGGGGCC
ATCACGACCGTGTATATTGACCAGACCATGGTGCTGGCCAGCGGAGGCCAAGACGGGGCC
ATCTGCCTGTGGGACGTGCTGACCGGCAGCCGGGTCAGCCACATGTTCGCTCACCGTGGG
GATGTCACCTCCCTCACCTGCACCACCTCGTGCGTCATCAGCAGTGGCCTGGACGACCTC
ATCAGCATCTGGGACCGCAGCACGGGCATCAAGCTCTACTCCATCCAGCAGGACCTGGGC
TGTGGCGCGAGCCTGGGTGTCATCTCAGACAACCTGCTGGTGACCGGCGGCCAGGGCTGT
GTTTCCTTTTGGGACCTGAACTACGGGGACCTGTTACAGACAGTCTACCTGGGCAAGAAC
AGCGAGGCCCAGCCGGCCCGCCAGATCCTGGTGCTGGACAACGCTGCCATTGTCTGCAAC
TTTGGCAGCGAGCTCAGCCTGGTGTACGTGCCCTCTGTGCTGGAGAAGCTGGACTGA |
Enzyme 8 GenBank Gene ID |
BC148152  |
Enzyme 8 GeneCard ID |
SCAP  |
Enzyme 8 GenAtlas ID |
Not Available |
Enzyme 8 HGNC ID |
Not Available |
Enzyme 8 Chromosome Location |
Chromosome:3 |
Enzyme 8 Locus |
3p21.31 |
Enzyme 8 SNPs |
SNPJam Report  |
Enzyme 8 General References |
Not Available |
Enzyme 8 Metabolite References |
Not Available |
Enzyme 9
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|
Enzyme 9 ID |
2129 |
Enzyme 9 Name |
StAR-related lipid transfer protein 5 |
Enzyme 9 Synonyms |
- START domain-containing protein 5
- StARD5
|
Enzyme 9 Gene Name |
STARD5 |
Enzyme 9 Protein Sequence |
>StAR-related lipid transfer protein 5
MDLATAAQVSEAVAEKMLQYRRDKSGWKICREGNGVSVSWRPSVEFPGNLYKGEGIVNGT
PEQVWDCVKPLAGTLRAQWDENVNSFEIIESLTDTLLFSRTTTPSAVMKLISPRDFVDLI
LVRTYEDGTISSNAANVEHPSCPPNPAYVRGFNHPCGCFCEPLPGEPNKTSLVTFFQTDL
SGYLPQSVVDSFFPRSMAGFYANLEKAVKKFFG |
Enzyme 9 Number of Residues |
213 |
Enzyme 9 Molecular Weight |
23572.5 |
Enzyme 9 Theoretical pI |
5.06 |
Enzyme 9 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 9 General Function |
Not Available |
Enzyme 9 Specific Function |
May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols |
Enzyme 9 Pathways |
Not Available |
Enzyme 9 Reactions |
Not Available |
Enzyme 9 Pfam Domain Function |
|
Enzyme 9 Signals |
|
Enzyme 9 Transmembrane Regions |
|
Enzyme 9 Essentiality |
Not Available |
Enzyme 9 GenBank ID Protein |
119224061  |
Enzyme 9 UniProtKB/Swiss-Prot ID |
A1A4M6  |
Enzyme 9 UniProtKB/Swiss-Prot Entry Name |
STAR5_BOVIN  |
Enzyme 9 PDB ID |
Not Available |
Enzyme 9 Cellular Location |
Not Available |
Enzyme 9 Gene Sequence |
>642 bp
ATGGACCTGGCGACGGCCGCGCAGGTGAGCGAGGCGGTGGCGGAGAAGATGCTCCAGTAC
CGGCGAGACAAGTCAGGCTGGAAGATTTGCCGGGAAGGCAACGGAGTTTCAGTTTCCTGG
AGGCCATCTGTGGAGTTTCCAGGGAACCTGTACAAAGGAGAAGGCATTGTGAATGGGACA
CCAGAGCAGGTGTGGGACTGCGTGAAGCCACTTGCTGGGACTTTACGAGCTCAGTGGGAT
GAGAATGTGAACAGTTTTGAAATTATTGAAAGCCTCACTGATACCCTGCTCTTCAGCAGA
ACCACTACCCCCTCGGCCGTCATGAAGCTTATTTCCCCCAGAGACTTTGTGGACCTGATA
CTGGTCAGGACGTACGAGGACGGCACCATCAGTTCCAATGCTGCCAATGTGGAGCATCCA
TCTTGTCCCCCAAATCCAGCTTACGTGAGAGGATTTAACCATCCCTGTGGTTGTTTCTGT
GAACCTCTGCCAGGGGAGCCAAACAAAACCAGCTTGGTCACGTTCTTCCAGACTGACCTC
AGTGGTTACCTCCCACAGAGCGTCGTGGACTCCTTCTTCCCCCGCAGCATGGCTGGGTTC
TACGCCAACCTTGAGAAAGCAGTGAAGAAATTCTTTGGTTGA |
Enzyme 9 GenBank Gene ID |
BC126727  |
Enzyme 9 GeneCard ID |
STARD5  |
Enzyme 9 GenAtlas ID |
Not Available |
Enzyme 9 HGNC ID |
Not Available |
Enzyme 9 Chromosome Location |
Chromosome:1 |
Enzyme 9 Locus |
15q26 |
Enzyme 9 SNPs |
SNPJam Report  |
Enzyme 9 General References |
Not Available |
Enzyme 9 Metabolite References |
Not Available |
Enzyme 10
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|
Enzyme 10 ID |
2130 |
Enzyme 10 Name |
APOM protein |
Enzyme 10 Synonyms |
Not Available |
Enzyme 10 Gene Name |
APOM |
Enzyme 10 Protein Sequence |
>APOM protein
MAVGSAPMQLQLRATIRTKNGLCVPRKWIYHLSDGSTDLRTEGRPDMKTKLFSSACPGGI
MLKETGQGYQRFLLYNRSPHPPEKCVEEFQSLTSCLDFKAFLLTPRNQDACELSSN |
Enzyme 10 Number of Residues |
116 |
Enzyme 10 Molecular Weight |
13026.9 |
Enzyme 10 Theoretical pI |
8.76 |
Enzyme 10 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 10 General Function |
Involved in lipoprotein metabolic process |
Enzyme 10 Specific Function |
Not Available |
Enzyme 10 Pathways |
Not Available |
Enzyme 10 Reactions |
Not Available |
Enzyme 10 Pfam Domain Function |
Not Available |
Enzyme 10 Signals |
|
Enzyme 10 Transmembrane Regions |
|
Enzyme 10 Essentiality |
Not Available |
Enzyme 10 GenBank ID Protein |
73587088  |
Enzyme 10 UniProtKB/Swiss-Prot ID |
Q3ZBQ9  |
Enzyme 10 UniProtKB/Swiss-Prot Entry Name |
Q3ZBQ9_BOVIN  |
Enzyme 10 PDB ID |
Not Available |
Enzyme 10 Cellular Location |
Not Available |
Enzyme 10 Gene Sequence |
>351 bp
ATGGCTGTGGGCTCTGCCCCCATGCAGCTCCAGCTTCGAGCGACCATCCGCACGAAAAAC
GGGCTTTGCGTGCCCCGGAAATGGATCTACCACCTGTCTGATGGGAGCACAGATCTCAGA
ACTGAAGGCCGCCCTGACATGAAGACCAAGCTCTTCTCCAGTGCATGCCCAGGTGGAATC
ATGCTGAAAGAGACAGGCCAGGGTTACCAGCGCTTCCTCCTCTACAATCGCTCACCCCAC
CCTCCTGAGAAGTGTGTGGAGGAATTCCAGTCCCTGACCTCCTGCCTGGACTTTAAGGCC
TTCTTACTGACTCCCAGGAATCAAGACGCCTGTGAGCTGTCCAGTAACTGA |
Enzyme 10 GenBank Gene ID |
BC103165  |
Enzyme 10 GeneCard ID |
APOM  |
Enzyme 10 GenAtlas ID |
Not Available |
Enzyme 10 HGNC ID |
Not Available |
Enzyme 10 Chromosome Location |
Chromosome:6 |
Enzyme 10 Locus |
6p21.33 |
Enzyme 10 SNPs |
SNPJam Report  |
Enzyme 10 General References |
Not Available |
Enzyme 10 Metabolite References |
Not Available |
Enzyme 11
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|
Enzyme 11 ID |
2131 |
Enzyme 11 Name |
Steroidogenic acute regulatory protein, mitochondrial |
Enzyme 11 Synonyms |
- StAR
- START domain-containing protein 1
- StARD1
|
Enzyme 11 Gene Name |
STAR |
Enzyme 11 Protein Sequence |
>Steroidogenic acute regulatory protein, mitochondrial
MLLATFKLCAGSSYRHVRSMKGLQQQAVLAIGQELNRRALGGPAPAAWINQVRRRGSLLG
SQLEDPLYSDQELAYIQQGEEAMQRALGILKDQEGWKKESRQANGDEVLSKVIPDVGKVF
RLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTVITHELAAEVAGNLVG
PRDFVSVRCTKRRGSMCVLAGMATLYEEMPQQKGVIRAEHGPTCMVLRPLAGSPSRTKLT
WLLSIDLKGWLPKTIINQVLSQTQVDFANHLRKRLESCPALEARC |
Enzyme 11 Number of Residues |
285 |
Enzyme 11 Molecular Weight |
31870.8 |
Enzyme 11 Theoretical pI |
9.02 |
Enzyme 11 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 11 General Function |
Involved in cholesterol binding |
Enzyme 11 Specific Function |
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone |
Enzyme 11 Pathways |
- Steroid metabolism
- cholesterol metabolism
|
Enzyme 11 Reactions |
Not Available |
Enzyme 11 Pfam Domain Function |
|
Enzyme 11 Signals |
|
Enzyme 11 Transmembrane Regions |
|
Enzyme 11 Essentiality |
Not Available |
Enzyme 11 GenBank ID Protein |
3129956  |
Enzyme 11 UniProtKB/Swiss-Prot ID |
Q28918  |
Enzyme 11 UniProtKB/Swiss-Prot Entry Name |
STAR_BOVIN  |
Enzyme 11 PDB ID |
Not Available |
Enzyme 11 Cellular Location |
Not Available |
Enzyme 11 Gene Sequence |
>858 bp
ATGCTGCTCGCGACGTTTAAGCTGTGTGCCGGAAGCTCCTACAGACATGTGCGCAGCATG
AAGGGGCTGCAGCAGCAGGCTGTGCTGGCCATCGGCCAGGAGCTGAACCGGAGGGCCCTA
GGGGGCCCGGCCCCAGCTGCGTGGATTAACCAGGTTCGGCGTCGCGGCTCTCTCCTAGGT
TCTCAGCTGGAAGACCCTCTCTACAGCGACCAAGAGCTGGCCCATATCCAGCAGGGAGAG
GAGGCCATGCAGTGGGCCCTGGGCATCCTCAAAGACCAGGAGGGCTGGAAGAAGGAGAGC
CGGCAGGCCAATGGGGACGAGGTGCTGAGTAAAGTGATCCCTGACGTGGGCAAGGTGTTC
CGGTTGGAGGTGGTGGTGGACCAGCCCATGGAGAGGCTTTATGAAGAGCTTGTGGAGCGC
ATGGAGGCCATGGGCGAGTGGAATCCCAATGTCAAGGAGATCAAGGTCCTGCAGAAGATT
GGAAAAGACACGGTCATCACTCACGAGTTGGCTGCAGAGGCGGCAGGAAACCTCGTGGGG
CCCCGAGACTTTGTGAGCGTACGCTGTACCAAGCGCCGGGGCTCCATGTGTGTGCTGGCT
GGCATGGCCACACTCTATGAGGAGATGCCCCAGCAGAAGGGTGTCATCAGAGCGGAGCAC
GGCCCCACCTGCATGGTGCTCCGCCCCTTGGCTGGAAGTCCCTCAAGGACCAAACTCACC
TGGCTGCTCAGCATTGACCTCAAGGGATGGCTGCCGAAGACCATCATCAACCAGGTCCTC
TCGCAGACCCAGGTGGATTTTGCCAATCACCTGCGCAAGCGCCTGGAGTCCTGCCCTGCT
CTTGAAGCTAGGTGTTGA |
Enzyme 11 GenBank Gene ID |
Y17259  |
Enzyme 11 GeneCard ID |
STAR  |
Enzyme 11 GenAtlas ID |
Not Available |
Enzyme 11 HGNC ID |
Not Available |
Enzyme 11 Chromosome Location |
Chromosome:8 |
Enzyme 11 Locus |
8p11.2 |
Enzyme 11 SNPs |
SNPJam Report  |
Enzyme 11 General References |
- [PubMed
]
|
Enzyme 11 Metabolite References |
Not Available |
Enzyme 12
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|
Enzyme 12 ID |
2132 |
Enzyme 12 Name |
Apolipoprotein E |
Enzyme 12 Synonyms |
Not Available |
Enzyme 12 Gene Name |
Not Available |
Enzyme 12 Protein Sequence |
>Apolipoprotein E
LMEETMKEVKAYKEELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEV
QAMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSLSAIRERFG
PLVEQGQSRAATLSTLAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKIRQQLEEVHAK
VEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRPSPTSPPSENH |
Enzyme 12 Number of Residues |
237 |
Enzyme 12 Molecular Weight |
27073.5 |
Enzyme 12 Theoretical pI |
9.47 |
Enzyme 12 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 12 General Function |
Cell cycle control, cell division, chromosome partitioning |
Enzyme 12 Specific Function |
Not Available |
Enzyme 12 Pathways |
Not Available |
Enzyme 12 Reactions |
Not Available |
Enzyme 12 Pfam Domain Function |
|
Enzyme 12 Signals |
|
Enzyme 12 Transmembrane Regions |
|
Enzyme 12 Essentiality |
Not Available |
Enzyme 12 GenBank ID Protein |
110225417  |
Enzyme 12 UniProtKB/Swiss-Prot ID |
Q0ZCB4  |
Enzyme 12 UniProtKB/Swiss-Prot Entry Name |
Q0ZCB4_BOVIN  |
Enzyme 12 PDB ID |
Not Available |
Enzyme 12 Cellular Location |
Not Available |
Enzyme 12 Gene Sequence |
Not Available |
Enzyme 12 GenBank Gene ID |
DQ538523  |
Enzyme 12 GeneCard ID |
Not Available |
Enzyme 12 GenAtlas ID |
Not Available |
Enzyme 12 HGNC ID |
Not Available |
Enzyme 12 Chromosome Location |
Not Available |
Enzyme 12 Locus |
Not Available |
Enzyme 12 SNPs |
SNPJam Report  |
Enzyme 12 General References |
Not Available |
Enzyme 12 Metabolite References |
Not Available |
Enzyme 13
[top]
|
Enzyme 13 ID |
2133 |
Enzyme 13 Name |
Apolipoprotein E |
Enzyme 13 Synonyms |
Not Available |
Enzyme 13 Gene Name |
APOE |
Enzyme 13 Protein Sequence |
>Apolipoprotein E
MKVLWVAVVVALLAGCQADMEGELGPEEPLTTQQPRGKDSQPWEQALGRFWDYLRWVQTL
SDQVQEELLNTQVIQELTALMEETMKEVKAYKEELEGQLGPMAQETQARVSKELQAAQAR
LGSDMEDLRNRLAQYRSEVQAMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQ
AGASEGAERSLSAIRERFGPLVEQGQSRASTLSTLAGQPLLERAEAWRQKLHGRLEEVGV
RAQDRMDKIRQQLEEVHAKVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKV
QLALRPSPTSPPSENH |
Enzyme 13 Number of Residues |
316 |
Enzyme 13 Molecular Weight |
36072.7 |
Enzyme 13 Theoretical pI |
5.58 |
Enzyme 13 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 13 General Function |
Cell cycle control, cell division, chromosome partitioning |
Enzyme 13 Specific Function |
Not Available |
Enzyme 13 Pathways |
Not Available |
Enzyme 13 Reactions |
Not Available |
Enzyme 13 Pfam Domain Function |
|
Enzyme 13 Signals |
|
Enzyme 13 Transmembrane Regions |
|
Enzyme 13 Essentiality |
Not Available |
Enzyme 13 GenBank ID Protein |
157279088  |
Enzyme 13 UniProtKB/Swiss-Prot ID |
A7YWR0  |
Enzyme 13 UniProtKB/Swiss-Prot Entry Name |
A7YWR0_BOVIN  |
Enzyme 13 PDB ID |
Not Available |
Enzyme 13 Cellular Location |
Not Available |
Enzyme 13 Gene Sequence |
>951 bp
ATGAAGGTTCTGTGGGTTGCCGTGGTGGTCGCGCTTCTGGCAGGATGCCAGGCGGATATG
GAGGGAGAGCTGGGGCCCGAGGAGCCCCTGACTACGCAGCAGCCCCGGGGGAAGGACAGC
CAGCCTTGGGAGCAGGCGCTGGGCCGCTTCTGGGATTACCTGCGCTGGGTGCAGACCCTG
TCTGACCAGGTGCAGGAGGAGCTGCTCAACACCCAGGTCATTCAGGAACTGACGGCGCTG
ATGGAGGAGACCATGAAGGAGGTGAAGGCCTACAAGGAGGAGCTGGAGGGACAGCTAGGC
CCCATGGCCCAGGAGACACAGGCCCGCGTGTCCAAGGAGCTGCAGGCAGCCCAGGCCCGG
CTAGGCTCCGACATGGAGGACTTGCGGAACCGCCTGGCACAGTACCGAAGCGAGGTGCAG
GCCATGCTGGGCCAGTCTACCGAGGAGCTGCGGGCCCGCATGGCCTCCCACCTGCGCAAG
CTGCGCAAGCGGCTGCTCCGCGACGCTGACGACCTGAAGAAGCGCCTGGCCGTCTACCAA
GCTGGGGCCAGCGAGGGTGCCGAGCGCAGCTTGAGCGCCATCCGCGAGCGCTTCGGGCCC
CTGGTGGAGCAGGGCCAATCGCGGGCATCCACCCTGAGCACCCTGGCCGGCCAGCCGCTG
CTGGAGCGTGCCGAGGCCTGGCGCCAGAAGCTGCACGGGCGCCTGGAGGAGGTGGGCGTC
CGGGCCCAGGACCGCATGGATAAGATACGCCAGCAGCTAGAGGAGGTGCACGCCAAGGTC
GAGGAGCAGGGCAACCAGATGCGCCTGCAGGCCGAGGCATTCCAGGCCCGCCTCAGGAGC
TGGTTCGAGCCCCTGGTGGAAGACATGCAGCGCCAGTGGGCTGGGCTGGTGGAGAAGGTG
CAGTTGGCTCTGCGCCCCAGCCCCACCTCTCCGCCCAGTGAGAATCATTGA |
Enzyme 13 GenBank Gene ID |
BC134729  |
Enzyme 13 GeneCard ID |
APOE  |
Enzyme 13 GenAtlas ID |
Not Available |
Enzyme 13 HGNC ID |
Not Available |
Enzyme 13 Chromosome Location |
Chromosome:1 |
Enzyme 13 Locus |
19q13.2 |
Enzyme 13 SNPs |
SNPJam Report  |
Enzyme 13 General References |
Not Available |
Enzyme 13 Metabolite References |
Not Available |
Enzyme 14
[top]
|
Enzyme 14 ID |
2134 |
Enzyme 14 Name |
Scavenger receptor class B member 1 |
Enzyme 14 Synonyms |
- SRB1
- SR-BI
|
Enzyme 14 Gene Name |
SCARB1 |
Enzyme 14 Protein Sequence |
>Scavenger receptor class B member 1
MGNLSRARRVTAALGFIGLLFAVLGIIMIVMVPSIIKQQVLKNVRIDPNSLSFNMWKEIP
VPFYLSVYFFNIVNPEGIIQGQKPQVQEHGPYVYREFRHKSNITFNNNDTVSFLEYRSYQ
FQPDKSRGQESDYIVMPNILVLSASMMMENRPGLLKLMMTLAFSTLGQRAFMNRTVGEIM
WGYDDPLIHLINQYFPNSLPFKGKFGLFAELNNSDSGLFTVFTGVKNFSRIHLVDKWNGV
SKVNYWHSDQCNMINGTSGQMWAPFMTPESSLEFYSPEACRSMKLVYKEQGVFGGIPTFR
FVAPSTLFANGSVYPPNEGFCPCRESGIQNVSTCRFNAPLFLSHPHFYNADPVLAEAVSG
LHPNPKEHSLFLDIHPVTGIPMNCSVKLQLSLFVKSVKGIGQTGNIQPVVLPLMWFEESG
AMEGETLETFYIQLVLMPKVLHYAQYVLLALGCVLLLIPIIYQIRSQEKCYLFWISFKKG
SKDKEAVQAYSEFLMTSAPKGTVLQEARL |
Enzyme 14 Number of Residues |
509 |
Enzyme 14 Molecular Weight |
57609.6 |
Enzyme 14 Theoretical pI |
8.51 |
Enzyme 14 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 14 General Function |
Involved in receptor activity |
Enzyme 14 Specific Function |
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity |
Enzyme 14 Pathways |
Not Available |
Enzyme 14 Reactions |
Not Available |
Enzyme 14 Pfam Domain Function |
|
Enzyme 14 Signals |
|
Enzyme 14 Transmembrane Regions |
|
Enzyme 14 Essentiality |
Not Available |
Enzyme 14 GenBank ID Protein |
2429348  |
Enzyme 14 UniProtKB/Swiss-Prot ID |
O18824  |
Enzyme 14 UniProtKB/Swiss-Prot Entry Name |
SCRB1_BOVIN  |
Enzyme 14 PDB ID |
Not Available |
Enzyme 14 Cellular Location |
Not Available |
Enzyme 14 Gene Sequence |
>1530 bp
ATGGGCAACCTCTCTAGAGCGCGCCGGGTGACCGCGGCGCTGGGTTTCATCGGGCTCCTC
TTCGCCGTGCTGGGCATTATCATGATCGTGATGGTGCCCTCAATCATCAAGCAGCAGGTC
CTCAAGAATGTGCGCATCGACCCCAACAGCCTGTCTTTCAACATGTGGAAGGAAATCCCT
GTCCCCTTCTACCTCTCTGTCTACTTTTTCAACATCGTCAACCCTGAGGGGATCATCCAA
GGCCAGAAGCCACAGGTGCAGGAGCACGGGCCTTATGTGTACAGGGAGTTCAGGCACAAG
AGCAACATCACCTTCAACAACAATGACACGGTGTCCTTCCTGGAGTACCGCAGCTACCAG
TTCCAGCCGGATAAGTCCCGCGGCCAGGAGAGCGACTACATCGTCATGCCCAACATCCTG
GTCTTGAGTGCGTCAATGATGATGGAGAACAGGCCCGGGCTCTTGAAGCTGATGATGACC
TTGGCGTTCAGCACGCTTGGCCAGCGTGCCTTCATGAACCGCACTGTTGGCGAGATCATG
TGGGGCTATGATGACCCCTTAATCCACCTCATCAATCAGTACTTCCCAAACTCGCTCCCC
TTCAAGGGCAAGTTCGGCTTATTTGCTGAGCTCAACAACTCCGATTCTGGCCTCTTCACC
GTGTTCACAGGGGTCAAAAACTTCAGCAGGATCCATCTCGTGGACAAGTGGAATGGAGTC
AGCAAGGTCAACTATTGGCATTCCGATCAGTGCAACATGATTAACGGAACTTCCGGGCAG
ATGTGGGCACCATTTATGACCCCTGAATCCTCGCTGGAATTTTACAGCCCTGAGGCCTGC
CGGTCCATGAAGCTCGTCTACAAGGAGCAGGGGGTGTTTGGAGGCATCCCCACCTTTCGC
TTCGTGGCTCCCAGCACCTTATTTGCCAACGGGTCCGTCTACCCGCCCAACGAGGGCTTC
TGCCCCTGCCGGGAGTCCGGAATCCAAAACGTCAGCACCTGCAGGTTCAATGCGCCCTTG
TTTCTCTCCCATCCTCACTTCTACAACGCTGACCCAGTCCTGGCAGAGGCAGTGTCTGGC
CTCCATCCTAACCCAAAAGAACATTCCTTGTTCCTGGACATCCACCCGGTCACCGGAATC
CCCATGAACTGCTCTGTGAAACTGCAGCTGAGCCTCTTCGTTAAGTCTGTGAAAGGCATC
GGACAAACTGGGAACATCCAGCCAGTGGTCCTGCCGCTAATGTGGTTCGAAGAGAGTGGA
GCAATGGAGGGTGAGACCCTTGAGACGTTCTATATCCAGCTGGTGTTGATGCCCAAAGTG
CTACACTATGCCCAGTATGTGCTCCTTGCCCTGGGCTGCGTCCTACTGCTCATCCCCATC
ATCTACCAAATCCGGAGCCAAGAGAAATGCTATTTATTTTGGATTAGTTTTAAAAAGGGC
TCAAAGGATAAGGAGGCCGTTCAGGCCTATTCTGAATTCCTGATGACATCAGCTCCCAAG
GGAACTGTACTGCAAGAAGCAAGACTGTAG |
Enzyme 14 GenBank Gene ID |
AF019384  |
Enzyme 14 GeneCard ID |
SCARB1  |
Enzyme 14 GenAtlas ID |
Not Available |
Enzyme 14 HGNC ID |
Not Available |
Enzyme 14 Chromosome Location |
Chromosome:1 |
Enzyme 14 Locus |
12q24.31 |
Enzyme 14 SNPs |
SNPJam Report  |
Enzyme 14 General References |
- [PubMed
]
|
Enzyme 14 Metabolite References |
Not Available |
Enzyme 15
[top]
|
Enzyme 15 ID |
2135 |
Enzyme 15 Name |
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 |
Enzyme 15 Synonyms |
- NHERF-3
- Sodium-hydrogen exchanger regulatory factor 3
- Na(+)/H(+) exchanger regulatory factor 3
- PDZ domain-containing protein 1
|
Enzyme 15 Gene Name |
PDZK1 |
Enzyme 15 Protein Sequence |
>Na(+)/H(+) exchange regulatory cofactor NHE-RF3
MASTFNPRECKLTKQEGNSYGFFLRIEKDTDGHLVRVIEKGSPAEKAGLQDGDRVLRING
VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAMKKQVDLKALGQSQEPSLNDKKAPS
VMNGGAQMWMQPRLCYLVKEGGSYGFSLKTVQGKNGVYMTDIKPQGVAMKAGVLADDHLI
EVNGENVEDASHEEVVEKVKKSGSRVTFLLVDKETDKHHSEQKIKVKRETASLKLLPCQP
RVVEMKKGSNGYGFYLRESPEQKGQIIKDIDPKSPAEKAGLKNNDLVVAVNGKSVESLDH
DSVVEMIRKGGDQTSLLVVDKETDNIYKLAGFSPFFYYQSQELPNGSVKEVPAPTPAPLE
VSSPETTEEVGDHKPKLCRLARGEDGYGFHLNAVRGQPGSFVKEVQKGGPADLAGLEDED
VIIEVNGVNMLDESYEKVVDRIQSSGKTVTLLVCGKKAYDYFQAKKIPIVSSMADPLDDD
PDPDEGRLEGSEQNSHMAEERERAHSTASHSSSNSEDTEM |
Enzyme 15 Number of Residues |
520 |
Enzyme 15 Molecular Weight |
57175.1 |
Enzyme 15 Theoretical pI |
5.11 |
Enzyme 15 GO Classification |
Function |
— |
Process |
— |
Component |
— |
|
Enzyme 15 General Function |
Posttranslational modification, protein turnover, chaperones |
Enzyme 15 Specific Function |
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function |
Enzyme 15 Pathways |
Not Available |
Enzyme 15 Reactions |
Not Available |
Enzyme 15 Pfam Domain Function |
|
Enzyme 15 Signals |
|
Enzyme 15 Transmembrane Regions |
|
Enzyme 15 Essentiality |
Not Available |
Enzyme 15 GenBank ID Protein |
74353938  |
Enzyme 15 UniProtKB/Swiss-Prot ID |
Q3T0X8  |
Enzyme 15 UniProtKB/Swiss-Prot Entry Name |
NHRF3_BOVIN  |
Enzyme 15 PDB ID |
Not Available |
Enzyme 15 Cellular Location |
Not Available |
Enzyme 15 Gene Sequence |
>1563 bp
ATGGCCTCCACCTTCAACCCCCGAGAATGTAAGCTAACCAAACAGGAAGGGAATAGCTAT
GGCTTCTTCCTGCGAATTGAGAAGGACACTGACGGCCACCTGGTCCGGGTGATTGAGAAG
GGTAGCCCAGCAGAGAAGGCGGGTCTCCAGGATGGAGACAGAGTTCTTAGGATCAATGGT
GTCTTCGTGGACAAGGAAGAGCATATGCAGGTTGTGGATCTGGTCAGAAAGAGTGGGAAT
TCAGTGACTTTACTAGTTCTGGATGGGGATTCCTACGAGAAAGCCATGAAAAAGCAAGTA
GACTTGAAAGCGTTGGGTCAAAGTCAGGAGCCGAGTTTGAATGATAAGAAGGCGCCCTCT
GTGATGAACGGAGGAGCACAGATGTGGATGCAGCCACGGCTCTGCTACCTAGTGAAGGAG
GGGGGTAGCTATGGCTTCTCTCTGAAAACTGTCCAAGGTAAAAATGGAGTGTACATGACA
GATATAAAACCTCAAGGTGTGGCTATGAAAGCTGGAGTGCTGGCTGATGACCACTTGATT
GAAGTGAATGGAGAGAATGTAGAGGATGCCAGCCACGAGGAGGTGGTTGAAAAGGTGAAG
AAGTCTGGAAGCCGTGTCACATTCCTGCTTGTGGACAAGGAAACTGACAAGCACCATAGC
GAGCAGAAGATAAAAGTCAAGAGAGAAACAGCCAGTTTGAAACTGCTACCCTGCCAGCCC
CGTGTTGTAGAGATGAAGAAGGGAAGCAATGGCTATGGTTTCTACTTGAGGGAAAGCCCA
GAACAGAAAGGTCAAATCATCAAGGACATAGATCCCAAAAGTCCAGCAGAAAAGGCTGGC
TTGAAGAACAATGACCTGGTGGTTGCTGTCAATGGCAAGTCTGTGGAGTCCCTTGATCAT
GACAGTGTGGTGGAAATGATTAGAAAGGGTGGAGATCAGACCTCTCTGCTGGTGGTAGAC
AAAGAGACAGACAACATCTATAAACTGGCTGGCTTTTCTCCATTCTTCTACTATCAAAGC
CAAGAGCTGCCTAATGGTTCTGTCAAGGAGGTTCCAGCTCCTACTCCTGCTCCTCTGGAG
GTCTCAAGCCCAGAAACTACAGAGGAAGTAGGAGATCATAAGCCTAAACTCTGCAGGCTG
GCTAGAGGTGAAGATGGCTATGGCTTTCACTTAAACGCGGTTCGGGGTCAGCCAGGCTCA
TTCGTCAAAGAGGTGCAGAAGGGCGGCCCTGCTGATCTGGCTGGGCTGGAGGATGAGGAC
GTCATCATTGAGGTGAATGGAGTGAACATGCTGGATGAGTCCTATGAGAAGGTGGTGGAC
AGAATCCAGAGCAGTGGCAAGACTGTCACACTCTTAGTCTGTGGAAAGAAGGCCTATGAT
TATTTCCAGGCTAAGAAAATCCCTATCGTTTCCTCCATGGCTGATCCGCTGGATGATGAC
CCTGATCCTGATGAAGGAAGGCTGGAAGGATCAGAGCAAAACTCACACATGGCAGAAGAA
AGAGAACGAGCCCACAGTACAGCCTCTCATTCTTCTTCCAATTCTGAAGACACAGAGATG
TGA |
Enzyme 15 GenBank Gene ID |
BC102213  |
Enzyme 15 GeneCard ID |
PDZK1  |
Enzyme 15 GenAtlas ID |
Not Available |
Enzyme 15 HGNC ID |
Not Available |
Enzyme 15 Chromosome Location |
Chromosome:1 |
Enzyme 15 Locus |
1q21 |
Enzyme 15 SNPs |
SNPJam Report  |
Enzyme 15 General References |
Not Available |
Enzyme 15 Metabolite References |
Not Available |