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Bovine Metabolome Database



Showing metabocard for Adenosine (BMDB00050)

Legend: metabolite field enzyme field

Version 1.0
Creation Date 2005-11-16 15:48:42
Update Date 2009-05-05 20:57:39
Accession Number BMDB00050
Common Name Adenosine
Description A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. For instance, adenosine plays an important role in energy transfer - as adenosine triphosphate (ATP) and adenosine diphosphate (ADP). It also plays a role in signal transduction as cyclic adenosine monophosphate, cAMP. Adenosine itself is both a neurotransmitter and potent vasodilator. When administered intravenously, adenosine causes transient heart block in the AV node. Because of the effects of adenosine on AV node-dependent supraventricular tachycardia, adenosine is considered a class V antiarrhythmic agent.
Synonyms
  1. 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
  2. 6-Amino-9beta-D-ribofuranosyl-9H-purine
  3. 9-beta-D-Arabinofuranosyladenine
  4. 9-beta-D-Ribofuranosidoadenine
  5. 9-beta-D-Ribofuranosyl-9H-purin-6-amine
  6. 9-beta-d-Ribofuranosyladenine
  7. 9beta-D-Ribofuranosyladenine
  8. 9beta-D-ribofuranosyl-9H-Purin-6-amine
  9. Adenine nucleoside
  10. Adenine riboside
  11. Adenocard
  12. Adenocor
  13. Adenoscan
  14. Adenosin
  15. Boniton
  16. Myocol
  17. Nucleocardyl
  18. Sandesin
  19. adenine-9beta-D-Ribofuranoside
  20. b-D-Adenosine
  21. beta-Adenosine
  22. 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose
  23. 6-Amino-9beta-delta-ribofuranosyl-9H-purine
  24. 9-beta-delta-Arabinofuranosyladenine
  25. 9-beta-delta-Ribofuranosidoadenine
  26. 9-beta-delta-Ribofuranosyl-9H-purin-6-amine
  27. 9-beta-delta-Ribofuranosyladenine
  28. 9beta-delta-Ribofuranosyladenine
  29. 9beta-delta-ribofuranosyl-9H-Purin-6-amine
  30. adenine-9beta-delta-Ribofuranoside
  31. beta-delta-Adenosine
  32. beta-D-Adenosine
Chemical IUPAC Name 2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Chemical Formula C10H13N5O4
Chemical Structure Structure
Chemical Taxonomy
Kingdom
  • Organic
Super Class
  • Nucleosides and Nucleoside conjugates
Class
  • Nucleoside Analogues
Sub Class
  • Deoxy nucleosides
Family
  • Mammalian_Metabolite
Species
  • primary alcohol; secondary alcohol; 1,2-diol; primary amine; primary aromatic amine; aromatic compound; heterocyclic compound
Biofunction
  • Component of Methionine metabolism; Component of Purine metabolism; Component of Selenoamino acid metabolism
Application
Source
  • Endogenous
Average Molecular Weight 267.241
Monoisotopic Molecular Weight 267.096741
Isomeric SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Canonical SMILES NC1=NC=NC2=C1N=CN2C1OC(CO)C(O)C1O
KEGG Compound ID C00212 Link Image
BioCyc ID ADENOSINE Link Image
BiGG ID 34273 Link Image
Wikipedia Link Adenosine Link Image
METLIN ID 86 Link Image
PubChem Compound 60961 Link Image
PubChem Substance 828107 Link Image
ChEBI ID 16335 Link Image
CAS Registry Number 58-61-7
InChI Identifier InChI=1/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
Synthesis Reference Liao, Ben-ren; Yuan, Zhen-wen. Synthesis of adenosine from inosine. Huaxue Shiji (2006), 28(10), 633-634.
Melting Point (Experimental) 235.5 oC
Experimental Water Solubility 7 mg/mL [Adenocard product monograph]; 37 mg/mL [HMP experimental] Source: PhysProp
Predicted Water Solubility 8.23 mg/mL [MEYLAN,WM et al. (1996)]; 14.0 mg/mL [Predicted by ALOGPS] Calculated using ALOGPS
Physiological Charge 0
State Solid
Experimental LogP/Hydrophobicity -1.05 [HANSCH,C ET AL. (1995)] Source: PhysProp
Predicted LogP/Hydrophobicity -1.21 [Predicted by ALOGPS]; -1.6 [Predicted by PubChem via XLOGP] Calculated using ALOGPS
Material Safety Data Sheet (MSDS)
MOL File Show
SDF File Show
PDB File Show
2D Structure
3D Structure
Experimental PDB ID 1BX4 Link Image
Experimental PDB File Show
Experimental PDB Structure
Experimental 1H NMR Spectrum Download Spectrum
Download FID (Varian)
Show Experimental Conditions Link Image
Experimental 13C NMR Spectrum Download Spectrum
Download FID (Bruker)
Show Experimental Conditions Link Image
Experimental 13C HSQC Spectrum Download Spectrum
Download FID (Bruker)
Show Experimental Conditions Link Image
Predicted 1H NMR Spectrum Show Image
Show Peaklist
Predicted 13C NMR Spectrum Show Image
Show Peaklist
Mass Spectrum
Low Energy
Download File
Show Experimental Conditions Link Image
Medium Energy
Download File
Show Experimental Conditions Link Image
High Energy
Download File
Show Experimental Conditions Link Image
Simplified TOCSY Spectrum Show Image
Show Peaklist
BMRB Spectrum Show Image
Show Peaklist
Cellular Location
  • Cytoplasm (Predicted from LogP)
  • Extracellular
  • lysosome
  • mitochondria
Biofluid Location
  • Breast_Milk
Tissue Location
Tissue References
All Tissues
Concentrations (Normal)
Biofluid Breast_Milk
Value 1.360 +/- 0.670 uM
Age N/A
Sex N/A
Condition Normal
Comments Raw.
References
Biofluid Breast_Milk
Value 1.400 uM
Age N/A
Sex N/A
Condition Normal
Comments Raw.
References
Biofluid Breast_Milk
Value NA NA
Age NA
Sex NA
Condition Normal
Comments Detected but not quantified in conventional whole milk
References
Concentrations (Abnormal) Not Available
Pathway Names
  • Purine Metabolism
HMDB Pathways
Name Purine Metabolism
Image Show Link Image
KEGG Pathways
Name Purine Metabolism
Image Show Link Image
SimCell Pathways
Name Purine Metabolism
Image Show Link Image
Graph Show Link Image
SBML Download (XML) Link Image
General References
  1. Wikipedia Link Image
Metabolic Enzymes
  1. Adenosylhomocysteinase
  2. Adenosylhomocysteinase
  3. Adenosine deaminase
  4. Adenosine A3 receptor
  5. Adenosine receptor A2b
  6. Cleavage and polyadenylation specificity factor subunit 5
  7. Adenosine receptor A1
Enzyme 1 [top]
Enzyme 1 ID 837
Enzyme 1 Name Adenosylhomocysteinase
Enzyme 1 Synonyms Not Available
Enzyme 1 Gene Name AHCYL1
Enzyme 1 Protein Sequence >Adenosylhomocysteinase
GVCVRRRWWRGPVGAPRCCFWCSCRRCRCPAVLDRGAEEARATAPQHPTRLSLGPGGRVG
ERVSEGAARAGGRAPVRERGGGGGSAAGPAGRGMSMPDAMPLPGVGEELKQAKEIEDAEK
YSFMATVTKAPKKQIQFADDMQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDD
EVSPREKQQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAK
IVGCTHITAQTAVLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDD
FWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSK
AGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCC
AALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDR
MKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNLSC
STVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTEL
TDDQAKYLGLNKNGPFKPNYYRY
Enzyme 1 Number of Residues 623
Enzyme 1 Molecular Weight 68584.8
Enzyme 1 Theoretical pI 8.26
Enzyme 1 GO Classification
Function
Process
Component
Enzyme 1 General Function Coenzyme transport and metabolism
Enzyme 1 Specific Function S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine
Enzyme 1 Pathways
  • Amino-acid biosynthesis
  • homocysteine biosynthesis
  • L- homocysteine from S-adenosyl-L-homocysteine:step 1/1
Enzyme 1 Reactions Not Available
Enzyme 1 Pfam Domain Function
Enzyme 1 Signals
  • None
Enzyme 1 Transmembrane Regions
  • None
Enzyme 1 Essentiality Not Available
Enzyme 1 GenBank ID Protein 148743914 Link Image
Enzyme 1 UniProtKB/Swiss-Prot ID A5PKK6 Link Image
Enzyme 1 UniProtKB/Swiss-Prot Entry Name A5PKK6_BOVIN Link Image
Enzyme 1 PDB ID Not Available
Enzyme 1 Cellular Location Not Available
Enzyme 1 Gene Sequence Not Available
Enzyme 1 GenBank Gene ID BC142522 Link Image
Enzyme 1 GeneCard ID AHCYL1 Link Image
Enzyme 1 GenAtlas ID Not Available
Enzyme 1 HGNC ID Not Available
Enzyme 1 Chromosome Location Chromosome:1
Enzyme 1 Locus 1p13.2
Enzyme 1 SNPs SNPJam Report Link Image
Enzyme 1 General References Not Available
Enzyme 1 Metabolite References Not Available
Enzyme 2 [top]
Enzyme 2 ID 838
Enzyme 2 Name Adenosylhomocysteinase
Enzyme 2 Synonyms Not Available
Enzyme 2 Gene Name AHCYL2
Enzyme 2 Protein Sequence >Adenosylhomocysteinase
MSVQVVSAAAAAKVPEVELKDLSPSEAEPQLGLSTAAVSAMAPPAGGGDPEAPAPAAERP
PAPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEALVSPDGTVTEAPRTVK
KQIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAASYTDSSDDETSPRDKQQKNS
KGNSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTA
VLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVE
GWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVN
DSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYV
TEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGH
SNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIILLAEGRLLNLSCSTVPTFVLSITA
TTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNK
NGPFKPNYYRY
Enzyme 2 Number of Residues 611
Enzyme 2 Molecular Weight 66773.6
Enzyme 2 Theoretical pI 7.39
Enzyme 2 GO Classification
Function
Process
Component
Enzyme 2 General Function Coenzyme transport and metabolism
Enzyme 2 Specific Function S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine
Enzyme 2 Pathways
  • Amino-acid biosynthesis
  • homocysteine biosynthesis
  • L- homocysteine from S-adenosyl-L-homocysteine:step 1/1
Enzyme 2 Reactions Not Available
Enzyme 2 Pfam Domain Function
Enzyme 2 Signals
  • None
Enzyme 2 Transmembrane Regions
  • None
Enzyme 2 Essentiality Not Available
Enzyme 2 GenBank ID Protein 151553602 Link Image
Enzyme 2 UniProtKB/Swiss-Prot ID A6QLP2 Link Image
Enzyme 2 UniProtKB/Swiss-Prot Entry Name A6QLP2_BOVIN Link Image
Enzyme 2 PDB ID Not Available
Enzyme 2 Cellular Location Not Available
Enzyme 2 Gene Sequence >1836 bp
ATGTCGGTGCAGGTCGTGTCAGCAGCTGCTGCCGCGAAGGTGCCTGAGGTGGAGCTGAAG
GACCTGAGCCCCTCCGAGGCGGAGCCGCAGCTGGGACTGAGCACAGCGGCCGTGAGCGCC
ATGGCCCCCCCAGCGGGTGGTGGGGACCCTGAAGCTCCAGCTCCGGCCGCGGAGCGGCCC
CCAGCCCCCGGTCCGGGATCGGGCCCCGCAGCGGCTCTCAGCCCGGCCGCTGGGAAAGTG
CCTCAGGCGTCGGCCATGAAGCGGAGCGACCCTCACCACCAGCATCAGAGGCACCGGGAC
GGCGGCGAAGCCCTGGTCAGCCCCGACGGCACCGTCACCGAGGCGCCGCGCACAGTCAAG
AAGCAGATCCAATTTGCTGATCAGAAGCAAGAATTCAATAAACGTCCCACCAAAATTGGA
CGTCGCTCTCTGTCTCGTTCGATTTCCCAGTCATCGACTGACAGCTACAGCTCAGCGGCT
TCATATACAGATAGCTCTGATGATGAGACCTCTCCTAGAGACAAACAGCAAAAGAACTCT
AAGGGGAACAGTGACTTCTGTGTCAAGAACATCAAACAGGCAGAGTTTGGACGAAGAGAA
ATTGAAATTGCTGAGCAAGAAATGCCAGCACTGATGGCTTTGCGGAAGAGAGCTCAAGGA
GAGAAACCTTTGGCCGGCGCCAAGATTGTGGGTTGCACACACATCACTGCCCAGACTGCT
GTGCTTATGGAAACTCTGGGAGCTCTGGGAGCACAGTGCCGATGGGCTGCCTGCAACATC
TATTCCACCCTCAACGAAGTGGCTGCTGCTCTAGCAGAAAGTGGATTTCCTGTGTTTGCC
TGGAAAGGAGAGTCAGAAGATGACTTCTGGTGGTGCATTGACAGATGTGTGAATGTGGAG
GGCTGGCAGCCAAACATGATCTTGGATGATGGAGGGGATCTTACTCACTGGATTTATAAG
AAGTATCCCAACATGTTTAAGAAAATCAAGGGCATAGTGGAGGAGAGTGTTACCGGAGTT
CATAGGCTCTACCAGCTATCCAAAGCTGGGAAGCTGTGTGTTCCAGCCATGAATGTCAAT
GACTCAGTCACGAAACAGAAATTTGACAACCTCTACTGTTGCCGTGAATCAATTCTTGAT
GGACTTAAAAGAACAACAGACATGATGTTTGGTGGGAAGCAGGTGGTAGTCTGTGGCTAT
GGAGAGGTCGGGAAGGGGTGCTGTGCTGCCTTGAAAGCTATGGGCTCCATTGTGTATGTG
ACTGAGATCGACCCCATCTGCGCTCTTCAAGCCTGTATGGATGGATTTCGACTGGTGAAA
TTAAATGAGGTCATCCGACAAGTGGATATTGTTATTACCTGTACAGGTAATAAGAATGTG
GTAACCAGAGAGCATTTAGATCGTATGAAGAATAGCTGCATTGTTTGTAACATGGGACAT
TCCAACACGGAGATTGATGTGGCAAGTCTGCGGACACCAGAACTGACGTGGGAGCGAGTG
AGATCCCAAGTTGATCATGTAATATGGCCTGACGGCAAGAGGATAATATTGTTGGCAGAG
GGCCGTCTGCTGAACCTAAGCTGCTCCACAGTGCCTACATTTGTGCTCTCAATCACTGCT
ACAACTCAGGCTCTAGCCTTGATAGAGCTCTACAATGCTCCCGAGGGTCGCTATAAGCAA
GATGTCTACCTGTTGCCCAAGAAAATGGATGAGTATGTGGCCAGCCTACACCTGCCCACC
TTTGATGCCCACCTGACTGAGCTGACAGATGAACAAGCCAAGTATCTAGGGCTCAACAAG
AATGGGCCCTTCAAGCCCAATTACTACAGGTATTAA
Enzyme 2 GenBank Gene ID BC148036 Link Image
Enzyme 2 GeneCard ID AHCYL2 Link Image
Enzyme 2 GenAtlas ID Not Available
Enzyme 2 HGNC ID Not Available
Enzyme 2 Chromosome Location Chromosome:7
Enzyme 2 Locus 7q32.1
Enzyme 2 SNPs SNPJam Report Link Image
Enzyme 2 General References Not Available
Enzyme 2 Metabolite References Not Available
Enzyme 3 [top]
Enzyme 3 ID 839
Enzyme 3 Name Adenosine deaminase
Enzyme 3 Synonyms
  1. Adenosine aminohydrolase
Enzyme 3 Gene Name ADA
Enzyme 3 Protein Sequence >Adenosine deaminase
MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPE
FLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAI
DLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGY
HTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIF
KSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAE
QCL
Enzyme 3 Number of Residues 363
Enzyme 3 Molecular Weight 40919.2
Enzyme 3 Theoretical pI 5.20
Enzyme 3 GO Classification
Function
Process
Component
Enzyme 3 General Function Nucleotide transport and metabolism
Enzyme 3 Specific Function Adenosine + H(2)O = inosine + NH(3)
Enzyme 3 Pathways Not Available
Enzyme 3 Reactions Not Available
Enzyme 3 Pfam Domain Function
Enzyme 3 Signals
  • None
Enzyme 3 Transmembrane Regions
  • None
Enzyme 3 Essentiality Not Available
Enzyme 3 GenBank ID Protein 9652182 Link Image
Enzyme 3 UniProtKB/Swiss-Prot ID P56658 Link Image
Enzyme 3 UniProtKB/Swiss-Prot Entry Name ADA_BOVIN Link Image
Enzyme 3 PDB ID 2BGN Link Image
Enzyme 3 PDB File Show
Enzyme 3 3D Structure
Enzyme 3 Cellular Location Not Available
Enzyme 3 Gene Sequence >1092 bp
ATGGCCCAGACGCCCGCCTTCAACAAGCCCAAAGTAGAACTGCATGTCCACCTGGATGGA
GCCATCAAGCCCGAAACCATCTTATATTATGGCAGGAAGAGGGGCATCGCCCTCCCCGCC
GACACGCCAGAGGAGCTACAGAACATCATCGGCATGGACAAGCCACTTAGCCTCCCAGAG
TTCCTGGCCAAGTTCGACTACTACATGCCTGCCATTGCGGGCTGCCGGGAGGCTGTCAAA
AGGATTGCCTACGAGTTTGTGGAGATGAAGGCCAAGGACGGCGTGGTGTATGTGGAGGTG
CGCTACAGCCCACACCTGCTGGCCAACTCCAAGGTGGAGCCGATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCGGATGAGGTGGTGTCACTGGTGAACCAGGGCCTGCAGGAGGGG
GAGCGGGACTTCGGCGTGAAGGTGCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAGC
TGGTCCTCTGAGGTGGTGGAGCTGTGTAAGAAGTACCGAGAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATTGAAGGCAGCAGCCTCTTCCCTGGACATGTGAAGGCC
TATGCGGAGGCCGTGAAGAGCGGCGTCCACCGCACGGTCCACGCCGGGGAAGTGGGCTCG
GCCAATGTGGTGAAAGAGGCCGTGGACACACTCAAGACCGAGAGGCTGGGGCATGGCTAC
CACACCCTGGAGGATGCCACCCTTTACAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
GTCTGCCCCTGGTCCAGCTACCTCACCGGCGCCTGGAAGCCCGACACGGAACACCCGGTT
GTTCGGTTCAAAAACGACCAGGTTAACTACTCGCTCAACACGGATGACCCGCTCATCTTC
AAGTCCACGCTGGACACGGATTACCAGATGACCAAGAATGAAATGGGCTTCACCGAAGAG
GAGTTTAAGAGACTGAACATCAATGCGGCCAAGTCCAGTTTCCTCCCTGAAGATGAGAAG
AAGGAGCTTCTTGATCTGCTCTATAAGGCCTACGGGATGCCCTCTCCGGCCTCTGCAGAG
CAGTGTCTGTGA
Enzyme 3 GenBank Gene ID AF280603 Link Image
Enzyme 3 GeneCard ID ADA Link Image
Enzyme 3 GenAtlas ID Not Available
Enzyme 3 HGNC ID Not Available
Enzyme 3 Chromosome Location Chromosome:2
Enzyme 3 Locus 20q12-q13.11
Enzyme 3 SNPs SNPJam Report Link Image
Enzyme 3 General References
  1. [PubMed Link Image]
Enzyme 3 Metabolite References Not Available
Enzyme 4 [top]
Enzyme 4 ID 2088
Enzyme 4 Name Adenosine A3 receptor
Enzyme 4 Synonyms Not Available
Enzyme 4 Gene Name ADORA3
Enzyme 4 Protein Sequence >Adenosine A3 receptor
MPVNSTAVSLASVTYISVEILIGLCAIVGNVLVIWVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVISLGVTIHFYSCLLMTCLLMIFTHASIMSLLAIAVDRYLRVKLTVRYRR
VTTQRRIWLALGLCWLVSFLVGLTPMFGWNMKLSSADKNLTFLPCQFRSVMRMDYMVYFS
FFTWILIPLVVMCAIYFDIFYVIRNRLSQNFSGSKETGAFYGREFKTAKSLSLVLFLFAL
SWLPLSIINCIIYFNGEVPQIVLYLGILLSHANSMMNPIVYAYKIKKFKETYLLILKACV
ICQPSKSMDPSIEQTSE
Enzyme 4 Number of Residues 317
Enzyme 4 Molecular Weight 35910.9
Enzyme 4 Theoretical pI 9.42
Enzyme 4 GO Classification
Function
Process
Component
Enzyme 4 General Function Not Available
Enzyme 4 Specific Function Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction
Enzyme 4 Pathways Not Available
Enzyme 4 Reactions Not Available
Enzyme 4 Pfam Domain Function
Enzyme 4 Signals
  • None
Enzyme 4 Transmembrane Regions
  • 15-37 49-72 85-106 127-148 177-197 231-254 261-283
Enzyme 4 Essentiality Not Available
Enzyme 4 GenBank ID Protein 111305440 Link Image
Enzyme 4 UniProtKB/Swiss-Prot ID Q0VC81 Link Image
Enzyme 4 UniProtKB/Swiss-Prot Entry Name AA3R_BOVIN Link Image
Enzyme 4 PDB ID Not Available
Enzyme 4 Cellular Location Not Available
Enzyme 4 Gene Sequence >954 bp
ATGCCTGTCAACAGTACTGCCGTGTCCTTGGCCAGCGTCACCTACATCTCTGTGGAGATT
CTCATCGGGCTCTGCGCCATAGTGGGCAACGTTCTGGTCATCTGGGTGGTCAAACTGAAC
CCCAGCCTACAGACCACCACCTTCTATTTCATTGTCTCCCTAGCTCTGGCTGACATTGCT
GTTGGGGTGCTGGTTATGCCTTTGGCCATTGTCATCAGCCTGGGTGTCACAATCCACTTT
TATAGCTGCCTTCTCATGACCTGCTTGCTGATGATCTTCACCCACGCATCCATCATGTCC
TTGCTAGCCATTGCCGTGGACCGATACCTGCGGGTCAAGCTCACAGTCAGATACAGGAGA
GTCACCACGCAAAGAAGAATATGGTTGGCTCTGGGCCTTTGCTGGCTGGTGTCATTCCTG
GTGGGATTGACCCCCATGTTTGGCTGGAACATGAAACTGAGCTCAGCAGACAAAAATCTT
ACCTTCCTACCCTGCCAATTCCGTTCGGTCATGAGGATGGATTACATGGTCTACTTCAGT
TTCTTCACGTGGATTCTCATTCCCCTGGTTGTCATGTGTGCCATCTACTTCGATATCTTC
TATGTCATCCGGAACCGACTCAGTCAGAACTTTTCTGGCTCCAAAGAGACAGGTGCATTC
TATGGACGGGAGTTCAAGACAGCCAAGTCTCTGTCACTGGTTCTTTTCTTGTTTGCTTTG
TCCTGGCTGCCTTTGTCCATCATCAACTGTATCATCTACTTTAACGGTGAAGTGCCACAA
ATTGTGCTGTACTTGGGCATCCTGCTCTCCCACGCCAACTCCATGATGAACCCTATCGTC
TATGCTTATAAAATAAAGAAGTTCAAGGAAACCTATCTCTTGATCCTCAAAGCCTGTGTG
ATCTGCCAGCCCTCTAAGTCCATGGACCCAAGCATTGAGCAGACTTCTGAGTAG
Enzyme 4 GenBank Gene ID BC120305 Link Image
Enzyme 4 GeneCard ID ADORA3 Link Image
Enzyme 4 GenAtlas ID Not Available
Enzyme 4 HGNC ID Not Available
Enzyme 4 Chromosome Location Chromosome:1
Enzyme 4 Locus 1p13.2
Enzyme 4 SNPs SNPJam Report Link Image
Enzyme 4 General References Not Available
Enzyme 4 Metabolite References Not Available
Enzyme 5 [top]
Enzyme 5 ID 2089
Enzyme 5 Name Adenosine receptor A2b
Enzyme 5 Synonyms Not Available
Enzyme 5 Gene Name ADORA2B
Enzyme 5 Protein Sequence >Adenosine receptor A2b
MPLEAQDAVYVALELALAALSVTGNVLVCAAVGTSSALQTPTNYFLVSLAAADVAVGLFA
IPFAVTISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGA
RARGVIAALWVLAFGIGLTPFLGWNDRKIATNCTEPGDAATNVSCCLIRCLFENVVPMSY
MVYFNFFGCVLPPLLIMLVIYVKIFLVACRQLQRTELMDHSRTVLQREIHAAKSLALIVG
IFALCWLPVHTINCASLFQPTWAKVKPKWAINTAILLSHANSAVNPIVYAYRNRDFRYTF
HKIISRYILCRTHILKSGEGQVGSQPTLQLGL
Enzyme 5 Number of Residues 332
Enzyme 5 Molecular Weight 36384.7
Enzyme 5 Theoretical pI 8.82
Enzyme 5 GO Classification
Function
Process
Component
Enzyme 5 General Function Involved in adenosine receptor activity, G-protein coupled
Enzyme 5 Specific Function Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Enzyme 5 Pathways Not Available
Enzyme 5 Reactions Not Available
Enzyme 5 Pfam Domain Function
Enzyme 5 Signals
  • None
Enzyme 5 Transmembrane Regions
  • 9-33 44-67 79-101 122-144 178-202 235-258 267-290
Enzyme 5 Essentiality Not Available
Enzyme 5 GenBank ID Protein 94534865 Link Image
Enzyme 5 UniProtKB/Swiss-Prot ID Q1LZD0 Link Image
Enzyme 5 UniProtKB/Swiss-Prot Entry Name AA2BR_BOVIN Link Image
Enzyme 5 PDB ID Not Available
Enzyme 5 Cellular Location Not Available
Enzyme 5 Gene Sequence >999 bp
ATGCCGCTGGAGGCGCAGGACGCGGTGTACGTGGCGCTGGAGCTGGCTCTGGCCGCGCTG
TCGGTGACCGGCAACGTGTTGGTGTGCGCGGCGGTGGGCACCTCGAGCGCGCTGCAGACG
CCCACCAACTACTTTTTGGTGTCGCTGGCCGCGGCCGACGTGGCCGTGGGGCTGTTCGCC
ATCCCCTTCGCCGTCACCATCAGCCTGGGCTTCTGCACCGACTTCCACAGCTGCCTCTTC
CTCGCCTGCTTTGTGCTGGTGCTCACGCAGAGCTCCATCTTCAGCCTCCTGGCCGTGGCC
GTCGACAGATACCTGGCCGTGCGCGTCCCGCTCAGGTATAAGAGTCTGGTCACTGGGGCC
CGAGCGAGAGGAGTCATTGCTGCCCTCTGGGTCCTGGCCTTTGGCATTGGCCTGACACCG
TTCTTGGGGTGGAACGACAGAAAAATTGCCACCAACTGCACAGAGCCGGGGGATGCAGCC
ACGAACGTGAGCTGCTGCCTCATCAGGTGTCTCTTCGAAAACGTGGTGCCCATGAGCTAC
ATGGTGTACTTCAACTTCTTCGGCTGCGTCCTGCCCCCACTGCTCATCATGCTGGTCATC
TACGTCAAGATCTTCCTGGTGGCCTGCAGGCAGCTACAGCGCACAGAGCTCATGGATCAC
TCAAGGACCGTCCTCCAGCGGGAGATCCACGCGGCCAAGTCCCTGGCCTTGATCGTTGGC
ATCTTCGCCCTGTGCTGGCTGCCAGTCCACACCATCAACTGTGCCTCACTCTTCCAGCCA
ACCTGGGCCAAGGTGAAGCCCAAGTGGGCGATAAACACAGCCATCCTCCTGTCGCATGCC
AACTCGGCTGTCAACCCCATCGTCTACGCCTACCGGAACCGAGACTTCCGCTACACTTTT
CACAAAATCATTTCCAGGTACATCCTCTGCCGGACGCACATCCTCAAGAGTGGGGAGGGG
CAGGTGGGGTCGCAGCCCACTCTCCAGCTGGGCCTATGA
Enzyme 5 GenBank Gene ID BC116078 Link Image
Enzyme 5 GeneCard ID ADORA2B Link Image
Enzyme 5 GenAtlas ID Not Available
Enzyme 5 HGNC ID Not Available
Enzyme 5 Chromosome Location Chromosome:1
Enzyme 5 Locus 17p12-p11.2
Enzyme 5 SNPs SNPJam Report Link Image
Enzyme 5 General References Not Available
Enzyme 5 Metabolite References Not Available
Enzyme 6 [top]
Enzyme 6 ID 2090
Enzyme 6 Name Cleavage and polyadenylation specificity factor subunit 5
Enzyme 6 Synonyms
  1. Nucleoside diphosphate-linked moiety X motif 21
  2. Nudix motif 21
Enzyme 6 Gene Name NUDT21
Enzyme 6 Protein Sequence >Cleavage and polyadenylation specificity factor subunit 5
MSVVPPNRSQTGWPRGVTQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSV
AARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEG
LKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQ
EKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN
Enzyme 6 Number of Residues 227
Enzyme 6 Molecular Weight 26227.1
Enzyme 6 Theoretical pI 9.18
Enzyme 6 GO Classification
Function
Process
Component
Enzyme 6 General Function Involved in hydrolase activity
Enzyme 6 Specific Function Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export
Enzyme 6 Pathways Not Available
Enzyme 6 Reactions Not Available
Enzyme 6 Pfam Domain Function
Enzyme 6 Signals
  • None
Enzyme 6 Transmembrane Regions
  • None
Enzyme 6 Essentiality Not Available
Enzyme 6 GenBank ID Protein 73586913 Link Image
Enzyme 6 UniProtKB/Swiss-Prot ID Q3ZCA2 Link Image
Enzyme 6 UniProtKB/Swiss-Prot Entry Name CPSF5_BOVIN Link Image
Enzyme 6 PDB ID Not Available
Enzyme 6 Cellular Location Not Available
Enzyme 6 Gene Sequence >684 bp
ATGTCCGTGGTGCCGCCCAATCGCTCGCAGACCGGCTGGCCCCGGGGAGTCACCCAGTTC
GGCAACAAGTATATCCAGCAGACCAAGCCCCTCACCCTGGAGCGCACCATCAACCTGTAC
CCTCTTACCAATTACACTTTTGGTACAAAAGAACCCCTCTATGAGAAGGACAGCTCTGTT
GCAGCCAGATTTCAGCGCATGAGGGAGGAATTTGATAAAATTGGCATGAGGAGGACTGTA
GAAGGGGTTTTGATTGTCCATGAGCACCGGCTACCCCATGTGTTACTGCTACAGCTGGGA
ACAACGTTCTTCAAATTACCTGGTGGTGAGCTTAATCCAGGAGAAGATGAAGTTGAAGGA
CTAAAACGCTTAATGACAGAGATATTGGGTCGTCAAGATGGAGTCCTGCAAGACTGGGTT
ATCGATGACTGCATTGGCAACTGGTGGAGACCAAATTTTGAGCCTCCTCAGTATCCATAT
ATTCCTGCACATATTACAAAACCTAAGGAACATAAGAAGTTGTTTCTGGTTCAGCTTCAA
GAGAAAGCCTTGTTTGCAGTCCCTAAAAATTACAAGCTGGTAGCTGCACCGCTATTTGAA
CTGTATGACAATGCACCTGGATATGGACCCATCATTTCTAGTCTCCCCCAGCTTTTGAGC
AGGTTCAATTTTATATACAACTGA
Enzyme 6 GenBank Gene ID BC102697 Link Image
Enzyme 6 GeneCard ID NUDT21 Link Image
Enzyme 6 GenAtlas ID Not Available
Enzyme 6 HGNC ID Not Available
Enzyme 6 Chromosome Location Chromosome:1
Enzyme 6 Locus 16q13
Enzyme 6 SNPs SNPJam Report Link Image
Enzyme 6 General References Not Available
Enzyme 6 Metabolite References Not Available
Enzyme 7 [top]
Enzyme 7 ID 2091
Enzyme 7 Name Adenosine receptor A1
Enzyme 7 Synonyms Not Available
Enzyme 7 Gene Name ADORA1
Enzyme 7 Protein Sequence >Adenosine receptor A1
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
PRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPVDEDAPAERPDD
Enzyme 7 Number of Residues 326
Enzyme 7 Molecular Weight 36592.4
Enzyme 7 Theoretical pI 8.90
Enzyme 7 GO Classification
Function
Process
Component
Enzyme 7 General Function Involved in adenosine receptor activity, G-protein coupled
Enzyme 7 Specific Function Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
Enzyme 7 Pathways Not Available
Enzyme 7 Reactions Not Available
Enzyme 7 Pfam Domain Function
Enzyme 7 Signals
  • None
Enzyme 7 Transmembrane Regions
  • 11-33 47-69 81-102 124-146 177-201 236-259 268-292
Enzyme 7 Essentiality Not Available
Enzyme 7 GenBank ID Protein 87 Link Image
Enzyme 7 UniProtKB/Swiss-Prot ID P28190 Link Image
Enzyme 7 UniProtKB/Swiss-Prot Entry Name AA1R_BOVIN Link Image
Enzyme 7 PDB ID Not Available
Enzyme 7 Cellular Location Not Available
Enzyme 7 Gene Sequence >981 bp
ATGCCGCCCTCCATCTCGGCCTTCCAGGCCGCATATATTGGCATCGAGGTGCTCATCGCC
CTGGTCTCTGTGCCTGGGAACGTGCTGGTGATCTGGGCGGTGAAGGTGAATCAGGCCTTG
CGGGATGCCACCTTCTGCTTCATCGTGTCACTGGCAGTGGCTGATGTGGCGGTGGGCGCT
CTGGTCATCCCGCTCGCCATCCTCATCAACATTGGGCCACGGACCTACTTCCACACCTGC
CTCAAGGTCGCCTGCCCTGTCCTCATCCTCACTCAGAGCTCCATCCTGGCCCTGCTGGCA
ATTGCTGTTGACCGCTACCTCCGTGTCAAGATCCCACTCAGGTACAAGACAGTGGTGACT
CCTCGAAGGGCTGTGGTGGCCATCACTGGCTGCTGGATTCTCTCCTTCGTGGTGGGCCTG
ACGCCCATGTTCGGCTGGAACAACCTGAGCGCGGTGGAGCGGGACTGGCTGGCCAATGGC
AGCGTGGGCGAGCCTGTGATTGAATGCCAGTTCGAGAAGGTCATCAGCATGGAGTACATG
GTCTACTTCAACTTCTTCGTGTGGGTGCTGCCCCCGCTGCTGCTCATGGTCCTCATCTAC
ATGGAGGTCTTCTATCTGATCCGCAAGCAGCTCAGCAAGAAGGTGTCGGCCTCCTCCGGA
GACCCGCAGAAGTACTATGGGAAGGAGCTGAAGATCGCCAAGTCGCTGGCCCTCATCCTC
TTCCTCTTCGCCCTCAGCTGGCTGCCCTTGCACATCCTCAACTGTATCACCCTCTTCTGC
CCTTCCTGCCACATGCCCAGGATCCTCATATACATCGCCATCTTCCTCTCACACGGCAAC
TCGGCCATGAACCCCATCGTCTACGCCTTCCGCATCCAGAAGTTCCGAGTGACCTTCCTT
AAGATCTGGAATGACCACTTCCGCTGCCAGCCTGCGCCCCCCATTGATGAGGATGCCCCA
GCAGAGAGACCCGATGACTAG
Enzyme 7 GenBank Gene ID X63592 Link Image
Enzyme 7 GeneCard ID ADORA1 Link Image
Enzyme 7 GenAtlas ID Not Available
Enzyme 7 HGNC ID Not Available
Enzyme 7 Chromosome Location Chromosome:1
Enzyme 7 Locus 1q32.1
Enzyme 7 SNPs SNPJam Report Link Image
Enzyme 7 General References
  1. [PubMed Link Image]
Enzyme 7 Metabolite References Not Available